Elucidation of the Mechanisms and Effects of Certain Anesthetic Interventions on Digestive Cancer Patients Subjected to Surgery

Contributions to the Elucidation of the Mechanisms and Effects by Which Certain Perianesthetic Interventions Modify Long-term Evolution of Patients With Digestive Cancers Subjected to Surgery

Digestive cancers (liver, colonic, pancreatic) have a high incidence and high mortality, their population prevalence is also increasing. Given that the anesthesia techniques and the agents used act directly and indirectly on the immune system during the perioperative period, influencing both the treatment and the prognosis of patients with colorectal cancer who undergo elective interventions, a series of perianesthetic interventions have been proposed in order to reduce morbidity-mortality perioperative.

Inclusion Criteria:

• 18 to 80 years old patients admitted for elective colorectal surgery

Exclusion Criteria:

• Pre-existing chronic pain
• Chronic medication that may interfere with pain: antiepileptics, NSAIDs, corticosteroids
• Contraindications to any of the medications in the study
• Significant psychiatric disorders (Axis I disorder) (major depressive disorders, bipolar disorders, schizophrenia, etc.)
• Hepatic (ALT and / or AST> 2 normal wave) or renal (serum creatinine> 2 mg / dl)
• Convulsive conditions that require medication in the last 2 years
• Planned regional analgesia and / or anesthesia (spinal or epidural)
• Corticosteroid-dependent asthma
• Autoimmune disorders
• Antiarrhythmic drugs (verapamil, propafenone, amiodarone) that may interfere with the antiarrhythmic action of lidocaine