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This project aims to systematically and deeply study the central mechanism of tinnitus using electroencephalogram, and further study the treatment mechanism of tinnitus in combination with sound treatment strategies, so as to provide a research basis for clinical treatment of tinnitus.
Tinnitus is one of the most common auditory disturbances in human. The treatment of tinnitus is always not effective, and the standardized treatment of tinnitus has been lacking. With the development of neuroimaging, neuroelectrophysiology and animal models of tinnitus, the central mechanism of tinnitus has been gradually revealed. The possible mechanisms of tinnitus are the increase of spontaneous discharge rate and synchronization of auditory central neurons caused by hearing deprivation, the change of brain topological structure, the reorganization of auditory cortex, and the disorder of limbic system and auditory central regulation of tinnitus patients. EEG, as an important means to study the cerebral cortex, has become an important technical support for the research on the central mechanism of tinnitus. Changes in activity in auditory brain areas associated with tinnitus have been observed using EEG/ERPs, and non-auditory brain areas such as the limbic system and frontal cortices have also been associated with tinnitus mechanisms. This project aims to systematically and deeply study the central mechanism of tinnitus using electroencephalogram, and further study the treatment mechanism of tinnitus in combination with sound treatment strategies, so as to provide a research basis for clinical treatment of tinnitus.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| volunteer | Other | 40 volunteer will not accept any treatment |
|
| patients with unmodified music group | Placebo Comparator | 40 participants in this group will listen to music without any modification |
|
| patients with modified tinnitus relieving music | Experimental | 40 participants in this group will listen to the music modified according to the matched dominant tinnitus pitch |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| music therapy | Other | music therapy: therapeutic sound according to the frequency and loudness of each patient's tinnitus sound, so as to reduce the tinnitus sound. |
|
| Measure | Description | Time Frame |
|---|---|---|
| electroencephalogram evaluation | latency | From date of randomization, assessed every 3 month, up to 24 month |
| electroencephalogram evaluation | peak | From date of randomization, assessed every 3 month, up to 24 month |
| electroencephalogram evaluation | amplitude | From date of randomization, assessed every 3 month, up to 24 month |
| the loudness of tinnitus | estimated by auditory facility, recorded by unit of dB | From date of randomization, assessed every 3 month, up to 24 month |
| the frequency of tinnitus | estimated by auditory facility, recorded by unit of Hz | From date of randomization, assessed every 3 month, up to 24 month |
| minimum masking level | the minimum volume to masking tinnitus, recorded by unit of dB | From date of randomization, assessed every 3 month, up to 24 month |
| Tinnitus Handicapped Inventory | Tinnitus disability is divided into four levels, the first level: 0-16 points, no disability; Level 2:18-36, slightly disabled; Level 3:38-56, moderate disability; Level 4:58-100, severe disability. | From date of randomization, assessed every 3 month, up to 24 month |
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Inclusion Criteria:
Exclusion Criteria:
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| ID | Term |
|---|---|
| D014012 | Tinnitus |
| ID | Term |
|---|---|
| D006311 | Hearing Disorders |
| D004427 | Ear Diseases |
| D010038 | Otorhinolaryngologic Diseases |
| D012678 | Sensation Disorders |
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| ID | Term |
|---|---|
| D009147 | Music Therapy |
| ID | Term |
|---|---|
| D026421 | Sensory Art Therapies |
| D000529 | Complementary Therapies |
| D013812 | Therapeutics |
| D012046 | Rehabilitation |
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| Hospital Anxiety and Distress Scale |
0-7 are asymptomatic; 8 -10 respectively belong to suspicious existence; 11 -21 must exist. |
| From date of randomization, assessed every 3 month, up to 24 month |
| D009461 |
| Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D000359 |
| Aftercare |
| D003266 | Continuity of Patient Care |
| D005791 | Patient Care |
| D011613 | Psychotherapy |
| D004191 | Behavioral Disciplines and Activities |