Change of Gut Microbiome and Symptom After H.Pylori Eradication Therapy in Patients With Functional Dyspepsia

Change of Gut Microbiome and Symptom After H.Pylori Eradication Therapy in Patients With Functional Dyspepsia

The aims of the investigators' study are to investigate the effect of H.pylori eradication on the human gut microbiome and symptoms of functional dyspepsia.

Accumulating evidence shows that Helicobacter pylori protects against some metabolic and immunological diseases in which the development of these diseases coincide with temporal or permanent dysbiosis. Helicobacter pylori eradication therapy has the potential to improve symptoms of functional dyspepsia. The aims of our study are to investigate the effect of H.pylori eradication on the human gut microbiome and symptoms of functional dyspepsia.

Inclusion Criteria:

• Patients who has diagnosed with functional dyspesia by Rome IV criteria

Exclusion Criteria:

• Known GI malignancy
• Previous Helicobater pylori eradication history
• Severe systemic disease
• Previous GI surgery
• Uncorrectable coagulopathy: INR > 1.5 or platelet < 50,000/ml
• Pregnant or breastfeeding women
• Atrophic gastritis, open type