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This study aims to evaluate the effect of Helicobacter pylori eradication on gastrointestinal symptoms in adult patients. H. pylori infection is a common cause of dyspepsia and other upper gastrointestinal complaints. The trial will assess whether successful eradication therapy leads to significant improvement in symptoms compared to baseline. Adult patients diagnosed with H. pylori infection will receive standard eradication treatment, and symptom changes will be monitored using validated questionnaires over a defined follow-up period.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| H. pylori-positive adults - Eradication therapy group - Adult patients with H. pylori infection | Adult patients with confirmed Helicobacter pylori infection who have received standard eradication therapy prescribed by their healthcare providers. The study will observe and evaluate changes in gastrointestinal symptoms after completion of the prescribed treatment, without altering or influencing the treatment regimen. |
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| Measure | Description | Time Frame |
|---|---|---|
| Change in gastrointestinal symptoms after Helicobacter pylori eradication. | Gastrointestinal symptom improvement will be assessed using the Gastrointestinal Symptom Rating Scale (GSRS). The GSRS consists of 15 items, each scored from 1 to 7, giving a total score range of: Minimum score: 1 (absence of symptoms) Maximum score: 7 (most severe symptoms) Higher scores indicate worse gastrointestinal symptoms. Change will be calculated by comparing baseline scores to follow-up scores after completion of eradication therapy. | 6 weeks |
| Eradication success rate. | Proportion of patients achieving confirmed eradication of Helicobacter pylori using non-invasive testing (either urea breath test or stool antigen test), performed after completing eradication therapy. | 8 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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Adult patients (≥18 years) diagnosed with Helicobacter pylori infection by invasive or non-invasive tests (urea breath test or stool antigen test) and who have completed standard eradication therapy prescribed by their healthcare providers. The population includes both male and female patients presenting with gastrointestinal symptoms such as dyspepsia.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Amany Usama | Contact | +201113063055 | Amany_osama_post@med.sohag.edu.eg | |
| Arafa | Contact | Amany_osama_post@med.sohag.edu.eg |
| Name | Affiliation | Role |
|---|---|---|
| Amany Usama | Department of Gastroenterology and Tropical medicine Sohag University Hospital | Principal Investigator |
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| ID | Term |
|---|---|
| D004415 | Dyspepsia |
| ID | Term |
|---|---|
| D012817 | Signs and Symptoms, Digestive |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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