Develop adverse event prediction and plaque phenotype classification models for patients with known or suspected carotid artery disease.

Develop adverse event prediction and plaque phenotype classification models using plaque morphology and composition assessment of CTA which has been validated by histology, applied to representative cohort of patients. Generalizability of models is enhanced by using validated rather than only raw image inputs. Demographic, clinical, and outcome data is collected for enrolled patients as well as information on events and interventions.

Inclusion Criteria:

• Subjects must have two (or more) neck CTAs at least 6 months apart of sufficient quality as documented in the vascuCAP Reading Manual.
• Atherosclerotic plaque must be visualized within the carotid artery.

Exclusion Criteria:

• Subjects without visible plaque within the carotid artery
• Subject with insufficient CTA image quality (defined strictly as documented in the vascuCAP Reading Manual)

All-comers, design, adjusted for demographic factors