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| Name | Class |
|---|---|
| Max Planck Research Unit for Neurogenetics | UNKNOWN |
| AZ Sint-Lucas Brugge | OTHER |
| Universitair Ziekenhuis Brussel | OTHER |
| Hospital Clinic of Barcelona |
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We aim to understand the mechanism of olfactory dysfunction in COVID-19.
In December 2019, a new coronavirus causing severe acute respiratory syndrome was described in Wuhan, China. This virus, later named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), spread worldwide and has been designated a pandemic by the World Health Organization.
By the beginning of March 2020, several Ear, Nose, Throat societies raised awareness of a frequent association between coronavirus disease 2019 (COVID-19) and smell disorders.
In the present study, the investigators wish to begin to understand the pathogenesis of olfactory dysfunction in COVID-19.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| COVID-19 positive or negative patients | Other | Hospitalised patients with or without COVID-19 (with or without olfactory dysfunctions) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Sampling of tissue | Other | In all groups of participants, tissue from the nasal cavity and olfactory system will be surgically removed |
|
| Measure | Description | Time Frame |
|---|---|---|
| Prevalence of SARS-CoV-2 in the sampled tissue | In the sampled tissues, the investigators will determine presence of SARS-CoV-2 by means of immunohistochemistry, RNA-scope and spatial transcriptomics | Immediately after death |
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Inclusion Criteria:
- Deceased hospitalised patients, tested positive or negative for SARS-CoV-2 for patient or control group respectively
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Laura Van Gerven | Contact | +3216336342 | laura.vangerven@uzleuven.be | |
| Marnick Clijsters | Contact | +3216336342 | marnick.clijsters@kuleuven.be |
| Name | Affiliation | Role |
|---|---|---|
| Laura Van Gerven | UZ/KU Leuven | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| UZ Leuven | Recruiting | Leuven | Vlaams-Brabant | 3000 | Belgium |
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| ID | Term |
|---|---|
| D000086582 | Anosmia |
| D000086382 | COVID-19 |
| ID | Term |
|---|---|
| D000857 | Olfaction Disorders |
| D012678 | Sensation Disorders |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
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| OTHER |
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| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D011024 | Pneumonia, Viral |
| D011014 | Pneumonia |
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
| D014777 | Virus Diseases |
| D018352 | Coronavirus Infections |
| D003333 | Coronaviridae Infections |
| D030341 | Nidovirales Infections |
| D012327 | RNA Virus Infections |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |