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| Name | Class |
|---|---|
| Hopital Lariboisière | OTHER |
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This study is a case-control study to characterize the molecular and cellular anomalies of the olfactory epithelium of COVID-19 patients with isolated anosmia, by comparison with the olfactory epithelium of non-infected subjects.
Olfactory and taste dysfunctions are common and early onset in COVID-19, especially in pauci symptomatic patients, and may be the main clinical manifestations of the infection. Olfactory dysfunction could result from infection of the olfactory system by SARS-CoV-2 or from inflammation induced by the virus. While the recent development of COVID-19 pulmonary lesion research has revealed a viral, inflammatory and vascular origin, factors that cause olfactory disorders in COVID-19 are just beginning.
Acute anosmia observed in some patients with COVID-19 could result from:
It is therefore necessary to conduct a virological, cellular, immunological and inflammatory study of the olfactory epithelium from COVID-19 patients with isolated anosmia to identify the origin of these olfactory disorders.
This study is a case-control study to characterize the molecular and cellular anomalies of the olfactory epithelium of COVID-19 patients with isolated anosmia, by comparison with the olfactory epithelium of non-infected subjects.
Following measures will be performed at inclusion :
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| COVID-19 patients | Subject consulting in the Lariboisière hospital (Paris) in the context of the COVID-19 screening care for a suspected SARS-CoV-2 infection |
| |
| Control subjects | Subject consulting in the ear, nose and throat department at the Lariboisière hospital (Paris) with no biologically confirmed COVID-19 or suspected COVID-19 in the past 8 weeks, and no symptoms suggestive of COVID-19 or another respiratory disease and therefore no recent anosmia or ageusia |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Nasal swab | Other | Nasal swab |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Molecular and cellular defects in olfactory epithelium | Ratio of olfactory sensory cells in the nasal cytological sample | 30 months |
| Measure | Description | Time Frame |
|---|---|---|
| Biological mechanisms involved in the pathogenesis of the disease | Multiple measurements will be analyzed to characterize the immune and inflamatory status of the olfactory mucosa (presence of infiltrated immune cells, activation state of the immune cells in the epithelium, cytokine and interleukin level) | 30 months |
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Inclusion Criteria:
COVID-19 patients
Controls
Exclusion Criteria (both COVID-19 patients and controls):
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COVID-19 patients and control subjects
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| Name | Affiliation | Role |
|---|---|---|
| Françoise LAZARINI, PhD | Institut Pasteur | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hôpital Lariboisière, Policlinique | Paris | France | ||||
| Hôpital Lariboisière, Service ORL |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33941622 | Result | de Melo GD, Lazarini F, Levallois S, Hautefort C, Michel V, Larrous F, Verillaud B, Aparicio C, Wagner S, Gheusi G, Kergoat L, Kornobis E, Donati F, Cokelaer T, Hervochon R, Madec Y, Roze E, Salmon D, Bourhy H, Lecuit M, Lledo PM. COVID-19-related anosmia is associated with viral persistence and inflammation in human olfactory epithelium and brain infection in hamsters. Sci Transl Med. 2021 Jun 2;13(596):eabf8396. doi: 10.1126/scitranslmed.abf8396. Epub 2021 May 3. |
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| ID | Term |
|---|---|
| D018352 | Coronavirus Infections |
| D045169 | Severe Acute Respiratory Syndrome |
| D000086582 | Anosmia |
| ID | Term |
|---|---|
| D003333 | Coronaviridae Infections |
| D030341 | Nidovirales Infections |
| D012327 | RNA Virus Infections |
| D014777 | Virus Diseases |
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| ID | Term |
|---|---|
| D013649 | Taste |
| ID | Term |
|---|---|
| D012677 | Sensation |
| D009424 | Nervous System Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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Nasal swabs
| Taste and olfactory function evaluation |
| Other |
Taste and olfactory function evaluation |
|
| Epidemiological characteristics |
Demographic variables (sex, age, blood type), risk factors (tobacco, overweight, diabetes, rhinosinusitis disease, respiratory allergy) |
| 30 months |
| Olfactory and taste dysfunction | Self-questionnaire taste and smell survey (TTS) | 30 months |
| Olfactory and taste dysfunction | Visual analogue scale (VAS) (units from 0 normal perception to 100 no perception) | 30 months |
| Paris |
| France |
| D007239 |
| Infections |
| D012141 | Respiratory Tract Infections |
| D012140 | Respiratory Tract Diseases |
| D000857 | Olfaction Disorders |
| D012678 | Sensation Disorders |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |