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The 3D-PRIME study will analyse whether use of 3D echocardiography can improve risk stratification and cardiovascular outcome in patients with mitral regurgitation of different etiologies.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Primary mitral regurgitation | Patients with mitral regurgitation due to mitral valve disease |
| |
| Secondary mitral regurgitation | Patients with mitral regurgitation due to ventricular or atrial disease |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Use of 3D echocardiography in patient follow-up | Diagnostic Test | Patients will undergo clinical and echocardiographic examination including detailed 3D echocardiography at study inclusion and at least one follow-up visit. |
| Measure | Description | Time Frame |
|---|---|---|
| Major cardiovascular event | Death, mitral valve intervention, heart failure hospitalization | 24 months |
| Measure | Description | Time Frame |
|---|---|---|
| All-cause death | 24 months | |
| Cardiovascular death | 24 months | |
| Mitral valve intervention |
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Inclusion Criteria:
Exclusion Criteria:
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A cohort of patients with chronic mitral regurgitation referred for clinical and echocardiographic assessment at the Heart Valve Clinic at Haukeland University Hospital in Bergen, Norway.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Dana Cramariuc, MD PhD | Contact | +4755976755 | cdan@helse-bergen.no |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Haukeland University Hospital | Recruiting | Bergen | 5021 | Norway |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41674514 | Derived | Cramariuc D, Berg-Hansen CE, Grymyr LMD, Sindre RB, Aas CL, Ajmone Marsan N, Hung J, Urheim S. Role of 3D left ventricular end-systolic volume in risk stratification and outcome prediction in significant mitral regurgitation. Eur Heart J Imaging Methods Pract. 2026 Jan 28;4(1):qyag016. doi: 10.1093/ehjimp/qyag016. eCollection 2026 Jan. | |
| 38469654 |
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| ID | Term |
|---|---|
| D008944 | Mitral Valve Insufficiency |
| ID | Term |
|---|---|
| D006349 | Heart Valve Diseases |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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Proteomics, metabolomics
| 24 months |
| Berg-Hansen CE, Sindre RB, Grymyr LMD, Rogge B, Valeur AE, Urheim S, Hung J, Cramariuc D. Sex differences in left atrial volumes, mechanics, and stiffness in primary mitral regurgitation-a combined 2D and 3D echocardiographic study. Eur Heart J Cardiovasc Imaging. 2024 Jul 31;25(8):1118-1126. doi: 10.1093/ehjci/jeae072. |