The study is particularly innovative as it will accurately analyze the microscopic characteristics of the stroma, tumor budding and mucin expression in adenocarcinomas of the pancreas, using a comparative approach of long-survivor/short-survival patients.

Inclusion Criteria:

• Patients > 18 years of age at diagnosis
• Primary pancreatic cancer patients operated on in one of the 4 centres between 2001 and 2016
• Histopathological diagnosis of excreto-pancreatic adenocarcinoma of the pancreas, ductal adenocarcinoma or classical adenocarcinoma
• Tissue blocks (FFPE) available (tumour/healthy tissue)
• Affiliated to a social security scheme

Exclusion Criteria:

• Absence of Primary Cancer Tissue Blocks (PCTBs)
• Paraffin block fixed in Bouin or AFA
• Patient Refusal
• Pancreatic cancer not corresponding to a conventional excretopancreatic adenocarcinoma such as: carcinoma on intraductal papillary mucinous neoplasm, endocrine tumor/carcinoma, acinar cell carcinoma, ...).
• Patient died due to post-surgical complications (death within 30 days post-surgery).
• Surgical resection of macroscopic R2 type.

Pancreatic adenocarcinoma patients operated on between 2001 and 2016.