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The objective of this study is to identify prognosis and predictive markers of response to treatments (surgery, chemotherapy,...) in patients with pancreatic adenocarcinoma. The effectiveness and tolerance of these treatments in current practice is also evaluated.
The modest efficacy of current therapies for pancreatic cancer calls for the development of prognostic factors to guide patient selection and clinical decision-making based on tumor aggressiveness and risk of death.
The aim of this study is to identify prognostic and predictive factors of response to treatments administered in pancreatic adenocarcinoma, based on a multicenter cohort established on a population derived from current clinical practice. By accurately stratifying patients according to their estimated survival, prognostic tools could aid therapeutic decisions and optimize patient selection in future clinical trials.
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| Measure | Description | Time Frame |
|---|---|---|
| Overall Survival (OS) rate | Defined as the time interval between the start date of treatment (surgery, first cycle of L1 chemotherapy, or first radiotherapy session) and the date of death regardless of the cause. Living or lost to follow-up patients will be censored at the date of the last news | Up to 7 years from the date of initial cancer diagnosis (or until death if it occurs before 17 years) |
| Measure | Description | Time Frame |
|---|---|---|
| Progression-free survival (PFS) rate | Defined as the time interval between the start date of treatment (surgery, first cycle of L1 chemotherapy, or first radiotherapy session) and the date of first progression or date of death regardless of the cause. Living patients without progression or lost to follow-up will be censored at the date of the last news | Up to 7 years |
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Exclusion Criteria:
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Retro-prospective (diagnosis between 2003 and 2022) and prospective (diagnosis between 2023 and 2030) cohorts of patients with pancreatic adenocarcinoma
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Angelique VIENOT, MD | Contact | 01402985 00 | regulatory.Affairs@gercor.com.fr |
| Name | Affiliation | Role |
|---|---|---|
| Angelique VIENOT, MD | CHRU de Besançon - Institut Régional Fédératif du Cancer (IRFC) de Franche-Comté | Principal Investigator |
| Anthony Turpin, MD | Hôpital Claude-Huriez | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU Jean Minjoz | Recruiting | Besançon | France |
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| Number of patient with objective response rate | Evaluation according to RECIST v1.1, Choi or iRECIST criteria. Study the population followed for pancreatic adenocarcinoma according to tumor stages (localized, borderline, locally advanced, metastatic or recurrent after surgery) and according to treatments. | Up to 7 years |
| Number of patient with stability rate | Evaluation according to RECIST v1.1, Choi or iRECIST criteria. Study the population followed for pancreatic adenocarcinoma according to tumor stages (localized, borderline, locally advanced, metastatic or recurrent after surgery) and according to treatments. | Up to 7 years |
| Number of patient with tumor progression | Evaluation according to RECIST v1.1, Choi or iRECIST criteria. Study the population followed for pancreatic adenocarcinoma according to tumor stages (localized, borderline, locally advanced, metastatic or recurrent after surgery) and according to treatments. | Up to 7 years |
| Number of patient with grade 3/4 treatment-related toxicities | Toxicity rates according to CTCAE v5.0 classification. Study the population followed for pancreatic adenocarcinoma according to tumor stages (localized, borderline, locally advanced, metastatic or recurrent after surgery) and according to treatments. | Up to 7 years |
| Number of patients who received maintenance treatment in the first-line | Study the profiles of patients receiving maintenance treatment in 1st-line chemotherapy | Up to 7 years |
| Number of patients who received second and third-line treatments | Study the profiles of patients receiving 2nd and 3rd lines of chemotherapy | Up to 7 years |
| Hôpital Beaujon | Recruiting | Clichy | France |
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| CHU - Henri Mondor | Not yet recruiting | Créteil | France |
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| CHU Lille | Recruiting | Lille | France |
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| Centre Léon Bérard | Not yet recruiting | Lyon | France |
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| HRU Nancy Site Brabois | Recruiting | Nancy | France |
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| Hôpital Georges Pompidou | Recruiting | Paris | France |
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| Hôpital Saint Antoine | Recruiting | Paris | France |
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| Institut Mutualiste Montsouris | Not yet recruiting | Paris | France |
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| CHU Poitiers | Not yet recruiting | Poitiers | France |
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| CHU Reims | Not yet recruiting | Reims | France |
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| CHU Pontchaillou | Not yet recruiting | Rennes | France |
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| Institut Curie | Not yet recruiting | Saint-Cloud | France |
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| IHU - Institut de chirurgie guidée par l'imagerie | Not yet recruiting | Strasbourg | France |
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| Hôpital Paul Brousse | Recruiting | Villejuif | France |
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