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It is known that intraocular pressure changes during pregnancy. Collagen structure changes during pregnancy to enable softening of the symphysis, whitening of the birth chanel, and, thus, ultimately to enable delivery of a child. The cornea consists of highly structured collagen fibers. Hence, it seams logically that corneal biomechanics also change during pregnancy.
It is known that intraocular pressure changes during pregnancy. Collagen structure changes during pregnancy to enable softening of the symphysis, whitening of the birth chanel, and, thus, ultimately to enable delivery of a child. The cornea consists of highly structured collagen fibers. Hence, it seams logically that corneal biomechanics also change during pregnancy.
Measurement of intraocular pressure is highly dependant on corneal properties. With the Corvis ST device by Ocular Inc. it is possible to measure intraocular pressure and investigated corneal biomechanics. The aim of this study is therefore to compare corneal biomechanical properties during the third trimester with corneal biomechanical properties at 3 months after delivery.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Pregnant women | Pregnant woman, age 18 to 38 yo, with uncomplicated singleton pregnancy and no ocular diseases. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Non-Contact measurement of corneal properties | Device | Corneal Properties will be measurement with the non-contact Corvis ST Air-Puff Tonometer by Oculus Inc. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in Deformation Amplitude | Change in Deformation Amplitude (in millimeters) at 3 month post delivery compared to during third trimester will be assessed. | at 3 month post delivery compared to during third trimester |
| Change in Applanation Length | Change in Applanation Length (in millimeters) at 3 month post delivery compared to during third trimester of the pregnancy will be assessed. | at 3 month post delivery compared to during third trimester of the pregnancy |
| Change in Corneal Velocity | Change in Corneal Velocity (in meters/second) at 3 month post delivery compared to during third trimester of the pregnancy will be assessed. | at 3 month post delivery compared to during third trimester of the pregnancy |
| Change in corneal thickness | Change in corneal thickness (in millimeters) at 3 month post delivery compared to during third trimester of the pregnancy will be assessed. | at 3 month post delivery compared to during third trimester of the pregnancy |
| Change in Intraocular pressure | Change in intraocular pressure (in millimeters of mercury, mmHg) at 3 month post delivery compared to during third trimester of the pregnancy will be assessed. | at 3 month post delivery compared to during third trimester of the pregnancy |
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Inclusion Criteria:
Exclusion Criteria:
female
healthy pregnant women with uncomplicated singleton pregnancy
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Marc o Toeteberg-Harms, MD, FEBO | Contact | +41442551111 | +41442551111 | marc.toeteberg@usz.ch |
| Belgin o Özsoy, MD | Contact | +41442551111 | +41442551111 | belgin.oezsoy@usz.ch |
| Name | Affiliation | Role |
|---|---|---|
| Marc Toeteberg-Harms, MD, FEBO | University Hospital Zurich, Dpt. of Ophthalmology | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Ophthalmology | Recruiting | Zurich | Canton of Zurich | 8091 | Switzerland |
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