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The use of Cyclodestruction procedures has been extended to patients with non-refractory glaucoma and good vision. Our aim is to compare the safety and efficacy of three cyclodestructive treatments; High Intensity Focused Ultrasound (HIFU) Cyclocoagulation versus micropulse cyclophotocoagulation (MP-CPC) versus transscleral continuous wave cyclophotocoagulation (CW-CPC) for the treatment of Primary open angle glaucoma.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| High Intensity Focused Ultrasound Cyclophotocoagulation (HIFU) | Active Comparator |
| |
| MicroPulse cyclophotocoagulation (MP-CPC) | Active Comparator |
| |
| Continuous Wave cyclophotocoagulation (CW-CPC) | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cyclophotocoagulation | Procedure | High Intensity Focused Ultrasound Cyclophotocoagulation (HIFU): parameters: 21 MHz frequency, 2.45 W acoustic power, with the activation of each transducer lasting 6 seconds MicroPulse cyclophotocoagulation (MP-CPC):Laser settings of 2 Watts (W) will be applied for a 90 seconds treatment time for each 180 degrees, with a duty cycle of 31.3%, which consists of 0.5ms "on time" and 1.1 ms "off-time" and delivering a total of 112,7 Joules Continuous Wave cyclophotocoagulation (CW-CPC): The laser settings used will be 1.250 W, 4s exposure time per burn, 22-24 burns per eye. |
| Measure | Description | Time Frame |
|---|---|---|
| Success rate. | The success will be defined as IOP between 6 and 21 mmHg and at least a 30% reduction in IOP with or without topical IOP lowering medications. | 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Frequency of complications | 6 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Ahmed M Abdelrahman, MD | Contact | 00201227394861 | ahmed.mostafa@kasralainy.edu.eg | |
| Heba M ElSaied, MD | Contact | 00201224645060 | hebamagdy13@yahoo.com |
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| ID | Term |
|---|---|
| D005902 | Glaucoma, Open-Angle |
| ID | Term |
|---|---|
| D005901 | Glaucoma |
| D009798 | Ocular Hypertension |
| D005128 | Eye Diseases |
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