The purpose of this study is to evaluate the effectiveness and the safety of the cyclocoagulation using High Intensity Focused Ulatrsound with the EYEOP1 device in glaucoma patients

Inclusion Criteria:

• Refractory Glaucoma
• IOP > 21 mm Hg
• No previous intraocular surgery or laser treatment during the 90 days before HIFU day
• Age > 18 years
• Informed consent sgned by the subject

Exclusion Criteria:

• Normal Tension Glaucoma
• Glaucoma drainage device implanted and still present in the eye to be treated
• History of ocular or retrobulbar tumor
• Ocular infection within 14 days prior to the HIFU procedure
• Aphakic patient
• Ocular disease other than glaucoma that may affect assessment of visual and/or IOP (choroidal hemorrhage or detachment, lens subluxation, thyroid ophthalmopathy, proliferative diabetic retinopathy, clinical significant macular edema)
• Pregnant or breast-feeding women, or lack of contraception use among women likely to have a child