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The purpose of this follow-up study is to investigate the efficacy and safety of autologous Adipose Tissue derived Mesenchymal stem cells (JOINTSTEM®) in patient with severe Knee Osteoarthritis.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| JOINTSTEM | Experimental | Long Term Follow-up after Jointstem Transplantation |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| JOINTSTEM | Biological | Autologous Adipose Tissue derived MSCs |
|
| Measure | Description | Time Frame |
|---|---|---|
| Adverse Events | Incidence of adverse events from baseline to 5 Years | 5 Years |
| Measure | Description | Time Frame |
|---|---|---|
| Change of Western Ontario and McMaster Universities Osteoarthritis Index(WOMAC) scores from baseline | Pain, stiffness, and physical function of the knee will be measured by the WOMAC score | 5 Years |
| WOMAC 3 subscale score |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| KANGIL KIM | KyungHee University Gangdong Hospital | Principal Investigator |
| WOOSUK LEE | Gangnam Severance Hospital | Principal Investigator |
| KICHEOR BAE | Keimyung University Dongsan Medical Center | Principal Investigator |
| YONG IN | The Catholic University of Korea | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Keimyung University Dongsan Medical Center | Daegu | 42601 | South Korea | |||
| KyungHee University Gangdong Hospital |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 42184973 | Derived | Park JB, Jang GY, Cho KY, Lee H, Kim KI. Factors affecting outcomes of intra-articular injection of autologous, culture-expanded, adipose-derived mesenchymal stem cells in knee osteoarthritis. Stem Cells Transl Med. 2026 May 18;15(6):szag027. doi: 10.1093/stcltm/szag027. |
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| ID | Term |
|---|---|
| D020370 | Osteoarthritis, Knee |
| ID | Term |
|---|---|
| D010003 | Osteoarthritis |
| D001168 | Arthritis |
| D007592 | Joint Diseases |
| D009140 | Musculoskeletal Diseases |
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Pain, stiffness, and physical function of the knee will be measured by the Western Ontario and McMaster Universities (WOMAC)
| 5 Years |
| SF-36 | The SF(Short Form)-36 Health Survey is a 36-item, patient-reported survey of patient health. | 5 Years |
| Measuring of Kellgren-Lawrence grade | Measuring of Kellgren-Lawrence grade through X-ray | 1, 2, 3, 4, 5 Years |
| Measuring of Femoro-tibial anatomical angle(FTA) | Measuring of FTA through X-ray | 1, 2, 3, 4, 5 Years |
| Measuring of Hip-Knee-Ankle angle(HKA) | Measureing of HKA through X-ray | 1, 2, 3, 4, 5 Years |
| Measuring of Joint Space Width | measuring Joint Space Width through X-ray | 1, 2, 3, 4, 5 Years |
| MRI scan | The cartilage defect area is measured using MRI | 1, 2, 3, 4, 5 Years |
| Seoul |
| 05278 |
| South Korea |
| Gangnam Severance Hospital | Seoul | 06273 | South Korea |
| The Catholic University of Korea, Seoul ST. Mary's Hospital | Seoul | 06591 | South Korea |
| D012216 |
| Rheumatic Diseases |