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This study is a long term follow-up study to investigate the safety of autologous transplantation of Adipose Tissue derived Mesenchymal stem cells (MSCs) in patient with Knee Osteoarthritis.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Long Term Follow-up after Jointstem Transplantation | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Jointstem | Drug | JOINTSTEM is an OA treatment that uses autologous adipose-derived mesenchymal stem cells. As it does not use allogenic tissues and is incubated without additional genetic modification or mechanical and chemical modification through differentiation, it is classified as 'autologous cell therapy' and is completely free of immunologic rejection. |
| Measure | Description | Time Frame |
|---|---|---|
| Adverse Events | Incidence of adverse events from baseline to 60 months | 60 months |
| Measure | Description | Time Frame |
|---|---|---|
| WOMAC score | Change from baseline on WOMAC (Western Ontario and McMaster Universities Arthritis Index) score | Baseline and 12 months |
| WOMAC 3 subscale score | Change from baseline on WOMAC 3 subscale (Pain, stiffness, and physical function) score |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| KangIl Kim, M.D., Ph.D. | KyungHee University Gangdong Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| KyungHee University Gangdong Hospital | Seoul | 05278 | South Korea | |||
| GangNam Severance Hospital |
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| ID | Term |
|---|---|
| D020370 | Osteoarthritis, Knee |
| ID | Term |
|---|---|
| D010003 | Osteoarthritis |
| D001168 | Arthritis |
| D007592 | Joint Diseases |
| D009140 | Musculoskeletal Diseases |
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| Baseline and 12 months |
| X-ray | X-ray perform to measure with Kellgren-Lawrence grade | Baseline and 12 months |
| Seoul |
| 06273 |
| South Korea |
| D012216 |
| Rheumatic Diseases |