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Use of proton pump inhibitors has been associated with hypomagnesemia. However, various case-control or prospective studies have found conflicting results with regards to proton pump inhibitors use and development of hypomagnesemia. Our aim was to evaluate the likelihood that proton pump inhibitors contributed to severe hypomagnesemia in a retrospective cohort of patients admitted with severe hypomagenesemia. We also aimed to look for risk factors leading to development of hypomagnesemia amongst users of proton pump inhibitors
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Case | Patients admitted with hypomagnesemia are evaluated for proton pump inhibitor use and likelihood of hypomagnesemia due to proton pump inhibitor use |
| |
| Control | Patients on long-term proton pump inhibitor without documented hypomagnesemia |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| proton pump inhibitor use | Drug | Patients using long term proton pump inhibitor |
|
| Measure | Description | Time Frame |
|---|---|---|
| Hypomagnesemia due to use with proton pump inhibitor | Number of patients with Hypomagnesemia related to use of proton pump inhibitor using Naranjo score | 2013 to 2016 |
| Measure | Description | Time Frame |
|---|---|---|
| Risk factors for Hypomagnesemia | Odds ratio of developing Hypomagnesemia with risk factors of age, gender, type of drug, dose of drug, chronic renal failure, use of diuretics | 2013 to 2016 |
| Hypocalcaemia |
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Inclusion Criteria:
Exclusion Criteria:
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Patients managed at a referral centre from 2013 - 2016. Cases were admitted to the referral centre and had documentation hypomagnesemia. Controls were prescribed a course of proton pump inhibitor during the same period
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| Name | Affiliation | Role |
|---|---|---|
| Troy H Puar, MRCP | Changi General Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Changi General Hospital | Singapore | 529889 | Singapore |
Anonymised pooled data
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| ID | Term |
|---|---|
| D001145 | Arrhythmias, Cardiac |
| D012640 | Seizures |
| D006996 | Hypocalcemia |
| D007008 | Hypokalemia |
| ID | Term |
|---|---|
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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Number of patients developing hypocalcemia
| 2013 to 2016 |
| Hypokalemia | Number of patients developing Hypokalemia | 2013 to 2016 |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
| D002128 | Calcium Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D014883 | Water-Electrolyte Imbalance |