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The purpose of this study is to estimate effects of different kinds, different dose of 5-HT3 receptor antagonists on prevention of hypotension after spinal anesthesia
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| ramosetron 0.3 mg | Active Comparator | preparation of ramosetron 0.3 mg |
|
| ondansetron 8 mg | Active Comparator | preparation of ondansetron 8mg |
|
| ondansetron 4 mg | Active Comparator | preparation of ondansetron 4mg |
|
| non 5-HT3 receptor antagonist | Placebo Comparator | preparation of normal saline 5 ml |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| ramosetron | Drug | before 5 minutes spinal anesthesia, injection of ramosetron 0.3 mg |
| |
| Measure | Description | Time Frame |
|---|---|---|
| prevention of hypotension by calcaulation the gap between baseline mean arterial pressure and lowest mean arterial pressure measured during 30 minutes after spinal anesthesia. | comparasion of significantly difference in the gap between baseline mean arterial pressure and lowest mean arterial pressure measured during 30 minutes after spinal anesthesia. | up to 30mins after spinal anesthesia |
| Measure | Description | Time Frame |
|---|---|---|
| prevention of hypotension bycalculation the gap baseline systolic and diastolic blood pressure and lowerst systolic and diastolic blood pressure | comparasion of significantly difference in the gap between baseline systolic arterial pressure and lowest systolic arterial pressure measured during 30 minutes after spinal anesthesia and the gap between baseline diastolic arterial pressure and lowest diastolic arterial pressure measured during 30 minutes after spinal anesthesia. |
| Measure | Description | Time Frame |
|---|---|---|
| occurrence ratio of shivering, nausea and vomiting, and usage doses of vasopressor (ephedrine or phenylephrine), and atropine | up to 30 min after spinal anesthesia |
Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seoul National University Hospital | Seoul | 110-744 | South Korea |
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| ID | Term |
|---|---|
| D007022 | Hypotension |
| D009325 | Nausea |
| D014839 | Vomiting |
| ID | Term |
|---|---|
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D012817 | Signs and Symptoms, Digestive |
| D012816 | Signs and Symptoms |
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| ID | Term |
|---|---|
| C071315 | ramosetron |
| D017294 | Ondansetron |
| ID | Term |
|---|---|
| D007093 | Imidazoles |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
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| ondansetron |
| Drug |
before 5 minutes spinal anesthesia, injection of ondansetron 8 mg |
|
| ondansetron | Drug | before 5 minutes spinal anesthesia, injection of ondansetron 4 mg |
|
| placebo | Drug | before 5 minutes spinal anesthesia, injection of normal saline 5 ml |
|
| up to 30mins after spinal anesthesia |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D002227 |
| Carbazoles |
| D007211 | Indoles |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D006575 | Heterocyclic Compounds, 3-Ring |