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The aim of this study is to evaluate the remineralizing capacity of Gum Arabic varnish and its implementation into clinical practice.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Gum Arabic varnish | Experimental | Gum arabic (Acacia senegal) is an exudate obtained from Acacia senegal stems and roots, and other similar African Acacia species. It consists mainly of high molecular weight polysaccharides high concentrations of calcium, magnesium, and potassium salts which can potentially increase tooth remineralization. |
|
| Sodium Fluoride varnish | Active Comparator | The gold standard remineralizing agent recommended by the guidelines. |
|
| 10% w/v CPP-ACP, 5% sodium fluoride varnish | Active Comparator | CPP-ACP is the most studied non fluoride remineralizing agent. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Gum Arabic varnish | Drug | Powdered exudate from various Acacia species, especially A. senegal (Leguminosae). |
|
| Measure | Description | Time Frame |
|---|---|---|
| Remineralization through determination of lesion progression or regression | Determination of lesion level by DIAGNOdent which provides a laser fluorescence feedback to give a numerical readout reflects the amount of demineraliztion. | Change from baseline at 3,6, 9 months |
| Measure | Description | Time Frame |
|---|---|---|
| Caries lesion activity assessment | Visual (change in Surface Appearance) - tactile ( change in Tactile Feeling of the surface by an explorer) | Change from baseline at 3,6, 9 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Rawda H. A.ElAziz, Post Phd | Contact | 00201001097200 | rawda.hesham@dentistry.cu.edu.eg | |
| Ahmed H. Samaha, BSc | Contact | Ahmed.hesham@dentistry.cu.edu.eg |
| Name | Affiliation | Role |
|---|---|---|
| Rawda H. A.ElAziz, Post Phd | Lecturer at faculty of Dentistry- Cairo University | Study Director |
| Rasha R Hassan | Assistant Professor at faculty of Dentistry- Cairo University | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Faculty of Dentistry | Cairo | 11331 | Egypt |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30296788 | Background | Philip N. State of the Art Enamel Remineralization Systems: The Next Frontier in Caries Management. Caries Res. 2019;53(3):284-295. doi: 10.1159/000493031. Epub 2018 Oct 8. | |
| 18036508 | Background | Onishi T, Umemura S, Yanagawa M, Matsumura M, Sasaki Y, Ogasawara T, Ooshima T. Remineralization effects of gum arabic on caries-like enamel lesions. Arch Oral Biol. 2008 Mar;53(3):257-60. doi: 10.1016/j.archoralbio.2007.10.004. Epub 2007 Nov 26. |
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| ID | Term |
|---|---|
| D003731 | Dental Caries |
| ID | Term |
|---|---|
| D017001 | Tooth Demineralization |
| D014076 | Tooth Diseases |
| D009057 | Stomatognathic Diseases |
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| ID | Term |
|---|---|
| D006170 | Gum Arabic |
| ID | Term |
|---|---|
| D053149 | Plant Gums |
| D001704 | Biopolymers |
| D011108 | Polymers |
| D046911 | Macromolecular Substances |
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| Proflourid Varnish,VOCO | Drug | 5% NaF varnish |
|
| MI Varnish,GC Japan Inc. | Drug | CPP-ACP with fluoride based varnish |
|
| Ahmed H. Samaha, BSc | Master's Degree student at faculty of Dentistry- Cairo University | Principal Investigator |
| D011134 |
| Polysaccharides |
| D002241 | Carbohydrates |
| D053147 | Plant Exudates |
| D001688 | Biological Products |
| D045424 | Complex Mixtures |