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The aim of this study is to evaluate the effect of preoperative parameters on surgical results in Descemet Membrane Endothelial Keratoplasty (DMEK) surgery.
In patients undergoing Descemet Membrane Endothelial Keratoplasty (DMEK) surgery; preoperative anterior chamber depth, angle parameters, axial length and corneal parameters will be evaluated. The effects of these parameters on surgical results will be examined.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Cohort | All patients |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Descemet membrane endothelial keratoplasty (DMEK) | Procedure | All participants underwent DMEK surgery |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in visual acuity | Change from baseline | Baseline and after surgery 1, 3, 6, and 12 months |
| Change in endothelial cell density | Change from baseline | after surgery 1, 3, 6, and 12 months |
| Measure | Description | Time Frame |
|---|---|---|
| Change in maximum (steepest) and minimum (flattest) keratometry values in the central corneal zone | Change from baseline | Baseline and after surgery 1, 3, 6, and 12 months |
| Change in anterior chamber depth |
| Measure | Description | Time Frame |
|---|---|---|
| Surgical complications | Complications occurring during the surgery will be recorded. | During surgery |
Inclusion Criteria:
Exclusion Criteria:
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Patients who developed pseudophakic bullous keratopathy, Fuchs endothelial dystrophy, endothelial insufficiency after herpetic endotheliitis and associated permanent corneal edema and therefore DMEK surgery.
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| Name | Affiliation | Role |
|---|---|---|
| Semih Çakmak, MD | Beyoglu Eye Training and Research Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Beyoğlu Eye Training and Research Hospital | Istanbul | 34420 | Turkey (Türkiye) |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 35810243 | Derived | Cakmak S, Kirgiz A, Yildirim Y, Taskoparan S, Genc S, Agca A. The effect of anterior segment parameters on surgical success of Descemet membrane endothelial keratoplasty: a prospective study. Int Ophthalmol. 2023 Jan;43(1):197-205. doi: 10.1007/s10792-022-02416-0. Epub 2022 Jul 10. |
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot_SAP | Yes | Yes | No | Study Protocol and Statistical Analysis Plan | May 24, 2019 |
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Change from baseline
| Baseline and after surgery 1, 3, 6, and 12 months |
| Change in axial length | Change from baseline | Baseline and after surgery 1, 3, 6, and 12 months |
| Change in central pachymetry | Change from baseline | Baseline and after surgery 1, 3, 6, and 12 months |
| Change in intraocular pressure | Change from baseline | Baseline and after surgery 1, 3, 6, and 12 months |
| Jun 4, 2020 |
| Prot_SAP_000.pdf |
| ICF | No | No | Yes | Informed Consent Form | May 24, 2019 | Jun 4, 2020 | ICF_001.pdf |
| ID | Term |
|---|---|
| D005642 | Fuchs' Endothelial Dystrophy |
| D016849 | Keratitis, Herpetic |
| D008310 | Malocclusion |
| ID | Term |
|---|---|
| D003317 | Corneal Dystrophies, Hereditary |
| D003316 | Corneal Diseases |
| D005128 | Eye Diseases |
| D015785 | Eye Diseases, Hereditary |
| D030342 | Genetic Diseases, Inborn |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D015828 | Eye Infections, Viral |
| D015817 | Eye Infections |
| D007239 | Infections |
| D006561 | Herpes Simplex |
| D006566 | Herpesviridae Infections |
| D004266 | DNA Virus Infections |
| D014777 | Virus Diseases |
| D007634 | Keratitis |
| D014076 | Tooth Diseases |
| D009057 | Stomatognathic Diseases |
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