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The purpose of this study is evaluate the outcome after posterior lamellar keratoplasty (DMEK and Ultra-thin DSAEK) for corneal transplantation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Endothelial Keratoplasty | Other | Descemet membrane endothelial keratoplasty DMEK Ultra-thin Descemet stripping automated endothelial keratoplasty Ultra-thin DSAEK |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Endothelial Keratoplasty | Other |
|
|
| Measure | Description | Time Frame |
|---|---|---|
| Visual acuity (change from baseline) | 1, 3, 6, and 12 months and annually |
| Measure | Description | Time Frame |
|---|---|---|
| Endothelial cell density (change from baseline) | 1, 3, 6, and 12 months and annually | |
| Intraocular pressure (change from baseline) | 1, 3, 6, and 12 months and annually | |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Anna-Karina Maier, MD | Contact | anna-karina.maier@charite.de |
| Name | Affiliation | Role |
|---|---|---|
| Necip Torun, MD | Department of Ophthalmology, Charité - Unviersitätsmedizin Berlin | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Ophthalmology, Charité - Universitätsmedizin Berlin | Recruiting | Berlin | State of Berlin | 13353 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 23928950 | Background | Maier AK, Gundlach E, Gonnermann J, Klamann MK, Eulufi C, Bertelmann E, Joussen AM, Torun N. Fellow Eye Comparison of Descemet Membrane Endothelial Keratoplasty and Penetrating Keratoplasty. Cornea. 2013 Oct;32(10):1344-8. doi: 10.1097/ICO.0b013e31829dd816. | |
| 23575642 | Background | Maier AK, Gundlach E, Klamann MK, Gonnermann J, Bertelmann E, Joussen AM, Torun N, Rieck PW. [Influence of donor lamella thickness on visual acuity after Descemet's stripping automated endothelial keratoplasty (DSAEK)]. Ophthalmologe. 2014 Feb;111(2):128-34. doi: 10.1007/s00347-013-2795-0. German. |
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| Manifest refraction (change from baseline) |
| 1, 3, 6, 12 months and annually |
| corneal pachymetry (change from baseline) | 1, 3, 6, 12 months and annually |
| Quality of Life, NEI-VFQ 25 (change from baseline) | Questionnaire | 3, 12 months, annualy |
| corneal topography (change from baseline) | 1, 3, 6, and 12 months and annually |
| Anterior Segment OCT of cornea and anterior chamber angle (change from baseline) | 1, 3, 6, and 12 months and annually |
| postoperative Medication (change from baseline) | 1,3,6 and 12 months and annually |
| Histological Sample of Recipient's Descemet Membrane | Recipient's Descemet Membrane | intraoperative |
| 23180233 | Background | Maier AK, Klamann MK, Torun N, Gonnermann J, Schroeter J, Joussen AM, Rieck P. Intraocular pressure elevation and post-DSEK glaucoma after Descemet;s stripping endothelial keratoplasty. Graefes Arch Clin Exp Ophthalmol. 2013 Apr;251(4):1191-8. doi: 10.1007/s00417-012-2203-5. Epub 2012 Nov 20. |
| 21872938 | Background | Guerra FP, Anshu A, Price MO, Giebel AW, Price FW. Descemet's membrane endothelial keratoplasty: prospective study of 1-year visual outcomes, graft survival, and endothelial cell loss. Ophthalmology. 2011 Dec;118(12):2368-73. doi: 10.1016/j.ophtha.2011.06.002. Epub 2011 Aug 27. |
| 23108011 | Background | van Dijk K, Ham L, Tse WH, Liarakos VS, Quilendrino R, Yeh RY, Melles GR. Near complete visual recovery and refractive stability in modern corneal transplantation: Descemet membrane endothelial keratoplasty (DMEK). Cont Lens Anterior Eye. 2013 Feb;36(1):13-21. doi: 10.1016/j.clae.2012.10.066. Epub 2012 Oct 26. |
| 33591041 | Derived | Gundlach E, Pilger D, Brockmann T, Dietrich-Ntoukas T, Joussen AM, Torun N, Maier AB. Recovery of Contrast Sensitivity After Descemet Membrane Endothelial Keratoplasty. Cornea. 2021 Sep 1;40(9):1110-1116. doi: 10.1097/ICO.0000000000002686. |
| 32705337 | Derived | Gundlach E, Spiller N, Pilger D, Dietrich-Ntoukas T, Joussen AM, Torun N, Maier AB. Impact of difficult unfolding and attachment of the graft lamella on the long-term outcome after Descemet membrane endothelial keratoplasty. Graefes Arch Clin Exp Ophthalmol. 2020 Nov;258(11):2459-2465. doi: 10.1007/s00417-020-04852-z. Epub 2020 Jul 23. |
| 26764881 | Derived | Maier AK, Gundlach E, Pilger D, Rubsam A, Klamann MK, Gonnermann J, Bertelmann E, Joussen AM, Torun N. Rate and Localization of Graft Detachment in Descemet Membrane Endothelial Keratoplasty. Cornea. 2016 Mar;35(3):308-12. doi: 10.1097/ICO.0000000000000740. |
| 24782475 | Derived | Gonnermann J, Maier AK, Klamann MK, Brockmann T, Bertelmann E, Joussen AM, Torun N. Posterior iris-claw aphakic intraocular lens implantation and Descemet membrane endothelial keratoplasty. Br J Ophthalmol. 2014 Sep;98(9):1291-5. doi: 10.1136/bjophthalmol-2014-304948. Epub 2014 Apr 29. |
| ID | Term |
|---|---|
| D005642 | Fuchs' Endothelial Dystrophy |
| D057129 | Iridocorneal Endothelial Syndrome |
| ID | Term |
|---|---|
| D003317 | Corneal Dystrophies, Hereditary |
| D003316 | Corneal Diseases |
| D005128 | Eye Diseases |
| D015785 | Eye Diseases, Hereditary |
| D030342 | Genetic Diseases, Inborn |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D007499 | Iris Diseases |
| D014603 | Uveal Diseases |
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| ID | Term |
|---|---|
| D057111 | Descemet Stripping Endothelial Keratoplasty |
| ID | Term |
|---|---|
| D016378 | Tissue Transplantation |
| D064987 | Cell- and Tissue-Based Therapy |
| D001691 | Biological Therapy |
| D013812 | Therapeutics |
| D016039 | Corneal Transplantation |
| D054140 | Refractive Surgical Procedures |
| D013508 | Ophthalmologic Surgical Procedures |
| D013514 | Surgical Procedures, Operative |
| D014180 | Transplantation |
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