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| Name | Class |
|---|---|
| Center for Health Technology and Services Research | OTHER |
| NOVA Medical School | OTHER |
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The mobilizing programme MobFood - mobilizing scientific knoweledge and technology to answer the current nutrition market challenges - is formed by a consortium of 47 collaborative entities, between the industry and ENESIIs (Entidades Não Empresariais do Sistema de Investigação e Inovação) and is financed by Structural European Funds of Investment.
The project is currently investigating and undertaking collaborative scientific and technological strategies based on R&D and innovation, in order to boost and promote a more competitive national food industry, capable of overcoming the current challenges, including those of the Millennial Generation. This group is particularly conscious of the impact of food behaviour and food choices on health but extremely vulnerable to dietary imbalance. Strategies to improve Millenials' nutrition while providing conscious food products are needed.
This study is a randomised, cross-over controlled trial designed to test the metabolic effect, particularly in terms of appetite control and glycaemic response of a breakfast kit (nutritionally balanced and innovative), recently developed as part of the collaborative project MobFood_PPS4.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| MobFood breakfast kit | Experimental |
| |
| Control isocaloric breakfast | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| MobFood breakfast kit | Other | Cereal biscuit with orange fruit, cheese with fruit preparation and beverage based on oat, milk and mocha (without added sugar), specifically developed for the project MobFood_PPS4. |
| Measure | Description | Time Frame |
|---|---|---|
| Differences in the incremental area under the curve (iAUC, mg/dl*min) for glucose response between the 2 arms | The iAUC for glucose will be calculated based on the concentration curve following consumption of the test and control products, over 2h | at CID1 (1 week after screening) and CID2 (at least 2 days after visit 1) |
| Differences in the iAUC (pmol/l*min) for glucagon-like peptide-1 (GLP-1) between the 2 arms | The iAUC for GLP-1 will be calculated based on the concentration curve following consumption of the test and control products, over 3h | at CID1 (1 week after screening) and CID2 (at least 2 days after visit 1) |
| Differences in the iAUC (pmol/l*min) for peptide YY (PYY) between the 2 arms | The iAUC for PYY will be calculated based on the concentration curve following consumption of the test and control products, over 3h | at CID1 (1 week after screening) and CID2 (at least 2 days after visit 1) |
| Differences in the iAUC (pmol/l*min) for cholecystokinin (CKK) between the 2 arms | The iAUC for CKK will be calculated based on the concentration curve following consumption of the test and control products, over 3h | at CID1 (1 week after screening) and CID2 (at least 2 days after visit 1) |
| Differences in the iAUC (pmol/l*min) for ghrelin between the 2 arms | The iAUC for ghrelin will be calculated based on the concentration curve following consumption of test and control products, over 3h | at CID1 (1 week after screening) and CID2 (at least 2 days after visit 1) |
| Differences in the iAUC (pmol/l*min) for glucagon between the 2 arms |
| Measure | Description | Time Frame |
|---|---|---|
| Differences in the iAUC (mg/dl*min) for triacylglycerides (TG) between 2 arms | The iAUC for TG will be calculated based on the concentration curve following consumption of the test and control products, over 3h | at CID1 (1 week after screening) and CID2 (at least 2 days after visit 1) |
| Differences in the iAUC for (mmol/l*min) non-esterified fatty acids (NEFA) between 2 arms |
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Inclusion Criteria:
Exclusion Criteria:
type 1 or type 2 diabetes; liver disease e.g. cirrhosis; malignancy; pancreatitis or other malabsorption; gastrointestinal disorders e. g. intestinal bowel disorder, celiac disease; previous weight loss surgery e.g. bariatric surgery; chronic respiratory, neurological, psychiatric, musculoskeletal diseases/conditions; diagnosed eating disorders.
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Conceição Calhau, PhD | Contact | 00351 218803035 | 20401 | ccalhau@nms.unl.pt |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| NOVA Medical School, NOVA University of Lisbon | Lisbon | Portugal |
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| ID | Term |
|---|---|
| D005247 | Feeding Behavior |
| ID | Term |
|---|---|
| D001522 | Behavior, Animal |
| D001519 | Behavior |
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| Control isocaloric breakfast | Other | White bread, butter and milk. |
|
The iAUC for glucagon will be calculated based on the concentration curve following consumption of the test and control products, over 3h |
| at CID1 (1 week after screening) and CID2 (at least 2 days after visit 1) |
The iAUC for NEFA will be calculated based on the concentration curve following consumption of the test and control products, over 3h |
| at CID1 (1 week after screening) and CID2 (at least 2 days after visit 1) |
| Differences in subjective feelings of hunger/satiety between the 2 arms | Difference in subjective feelings of hunger/satiety from fasting state to post-prandial state with the consumption of the test and control products | at CID1 (1 week after screening) and CID2 (at least 2 days after visit 1) |