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| Name | Class |
|---|---|
| Agriculture and Agri-Food Canada | OTHER_GOV |
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This clinical trial is being conducted to study whether eating certain meals will reduce your desire to eat and for a longer period of time compared to others and to determine the post-meal glucose response associated with each of these breakfast foods.
The study is divided into 3 phases. Each phase involves eating one of 3 different breakfasts every day for 1 month. The order of the breakfast products is random. During each phase participants will come to the research clinic for 4 visits (1 per week) for assessment of appetite-related sensations. Gastric emptying will be assessed at 1 visit per phase and post prandial glucose response will be measured at 1 visit per phase (Asper site only).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| breakfast #1 | Experimental | breakfast food containing high viscosity fibre |
|
| breakfast #2 | Experimental | breakfast food containing low viscosity fibre |
|
| Control | Placebo Comparator | breakfast food without viscous fibre |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| breakfast | Other |
|
| Measure | Description | Time Frame |
|---|---|---|
| Satiety | Total area under the curve (AUC) for hunger, fullness, desire to eat, and prospective consumption scales | before the breakfast and every 30 minutes after breakfast for 4 hours |
| Gastric emptying rate | 13C-Octanoic Acid will be incorporated into the breakfast food. Rate of gastric emptying will be determined by measuring 13C in breath samples. | before the breakfast and every 15 minutes after breakfast for 4 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Glucose and Insulin | Total area under the curve (iAUC, mmol*min/L) for both glucose and insulin | before the breakfast and at 15, 30, 45, 60, 90 and 120 minutes after the the breakfast. |
| Kilocalories |
| Measure | Description | Time Frame |
|---|---|---|
| Gastrointestinal side effects | Incidence and duration of gastrointestinal side effects. | 4 weeks |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Heather Blewett, Ph.D | I.H. Asper Clinical Research Institute/Agriculture and Agri-Food Canada | Principal Investigator |
| Nancy Ames, PhD | Richardson Centre for Functional Foods and Nutraceuticals/Agriculture and Agri-Food Canada | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| I.H. Asper Clinical Research Institute | Winnipeg | Manitoba | R2H 2A6 | Canada | ||
| Richardson Centre for Functional Foods and Nutraceuticals |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 19753601 | Background | Beck EJ, Tosh SM, Batterham MJ, Tapsell LC, Huang XF. Oat beta-glucan increases postprandial cholecystokinin levels, decreases insulin response and extends subjective satiety in overweight subjects. Mol Nutr Food Res. 2009 Oct;53(10):1343-51. doi: 10.1002/mnfr.200800343. | |
| 20122136 | Background | Blundell J, de Graaf C, Hulshof T, Jebb S, Livingstone B, Lluch A, Mela D, Salah S, Schuring E, van der Knaap H, Westerterp M. Appetite control: methodological aspects of the evaluation of foods. Obes Rev. 2010 Mar;11(3):251-70. doi: 10.1111/j.1467-789X.2010.00714.x. Epub 2010 Jan 29. |
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| ID | Term |
|---|---|
| D062408 | Breakfast |
| ID | Term |
|---|---|
| D062407 | Meals |
| D005502 | Food |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
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Measure the amount of kilocalories consumed throughout each test day.
| 1 day |
| Winnipeg |
| Manitoba |
| R3T 2N2 |
| Canada |
| 24434584 | Background | Pentikainen S, Karhunen L, Flander L, Katina K, Meynier A, Aymard P, Vinoy S, Poutanen K. Enrichment of biscuits and juice with oat beta-glucan enhances postprandial satiety. Appetite. 2014 Apr;75:150-6. doi: 10.1016/j.appet.2014.01.002. Epub 2014 Jan 14. |
| 19700035 | Background | Thondre PS, Henry CJ. High-molecular-weight barley beta-glucan in chapatis (unleavened Indian flatbread) lowers glycemic index. Nutr Res. 2009 Jul;29(7):480-6. doi: 10.1016/j.nutres.2009.07.003. |
| 15159223 | Background | de Graaf C, Blom WA, Smeets PA, Stafleu A, Hendriks HF. Biomarkers of satiation and satiety. Am J Clin Nutr. 2004 Jun;79(6):946-61. doi: 10.1093/ajcn/79.6.946. |
| D019602 |
| Food and Beverages |