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| Name | Class |
|---|---|
| Second Affiliated Hospital of Heilongjiang University of Chinese Medicine | OTHER |
| Shenzhen Baoan District People's Hospital | OTHER |
| Xiyuan Hospital of China Academy of Chinese Medical Sciences | OTHER |
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The patients with type 2 diabetes mellitus (T2DM) is expected to rise to 439 million in 2030, accounting for 7.7% the population in the world. There are nearly 10 million T2DM patients with mild cognitive impairment (MCI) among people over 65 years old , accounting for about 8% of the people over 65 years old in China. The medical cost for patients with T2DM/MCI is 2.5 to 4 times higher than those without T2DM. And T2DM will increase the risk of cognitive impairment, and lead to various complications which will bring serious social and medical economic burden.
It is critically important to identify effective treatments to enhance functional status of T2DM/MCI patients. Exercise has been shown to be beneficial for T2DM/MCI patients. As a Chinese traditional mind-body exercise that consists of both physical and mediation components, Tai Chi Chuan has been proved to be helpful in global cognition, memory, executive function and attention of MCI, and blood sugar of T2DM. However, the evidence of the effect of Tai Chi Chuan on T2DM/MCI patients is limited. The purpose of this study is to explore the effect of Tai Chi Chuan treating T2DM/MCI patients in cognitive function, balance, motor and sensation function, blood sugar, biochemistry profile and quality of life.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Tai Chi Chuan Group | Experimental | In addition to conventional medical treatment, participants will receive 3 sessions of 1-hour Tai Chi Chuan training per week for 24 weeks and standard diabetic care education. |
|
| Fitness Walking Group | Active Comparator | In addition to conventional medical treatment, participants will receive 3 sessions of 1-hour fitness walking training per week for 24 weeks and standard diabetic care education |
|
| Control group | Other | In addition to conventional medical treatment, participants will receive standard diabetic care education 0.5hour/session, 2 sessions/month for 6 months. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Tai Chi Chuan | Behavioral | Participants would take 24-form simplified Tai Chi Chuan 1 hour/session, 3sessions/week for 24 weeks. There were 10 minutes warm-up, 40 minutes Tai Chi Chuan lesson and 10 minutes cool-down exercises in the Tai Chi Chuan training. Besides, they would also take standard diabetic care education 0.5hour/session, 2 sessions/month for 6 months. |
| Measure | Description | Time Frame |
|---|---|---|
| Global cognition-Montreal Cognitive Assessment at 36 Weeks | Montreal Cognitive Assessment | 36 weeks (post-intervention follow-up) |
| Measure | Description | Time Frame |
|---|---|---|
| Global cognition-Montreal Cognitive Assessment at 24 weeks | Montreal Cognitive Assessment | 24 weeks (post-intervention) |
| Memory function-Wechsler Memory Scale at 24, 36 Weeks | Wechsler Memory Scale |
| Measure | Description | Time Frame |
|---|---|---|
| Blood glucose metabolism index at 24, 36 weeks | fasting blood glucose; glycosylated hemoglobin; fasting insulin | 24, 36 weeks |
| Blood lipid metabolism index at 24, 36 weeks | total cholesterol (TC); total triglyceride (TG); low density lipoprotein (LDL),;high density lipoprotein (HDL). |
Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Fujian University of Traditional Chinese Medicine | Fuzhou | Fujian | 350122 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33417039 | Background | You Y, Liu Z, Chen Y, Xu Y, Qin J, Guo S, Huang J, Tao J. The prevalence of mild cognitive impairment in type 2 diabetes mellitus patients: a systematic review and meta-analysis. Acta Diabetol. 2021 Jun;58(6):671-685. doi: 10.1007/s00592-020-01648-9. Epub 2021 Jan 8. | |
| 33542702 | Background | Qin J, Chen Y, Guo S, You Y, Xu Y, Wu J, Liu Z, Huang J, Chen L, Tao J. Effect of Tai Chi on Quality of Life, Body Mass Index, and Waist-Hip Ratio in Patients With Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis. Front Endocrinol (Lausanne). 2021 Jan 19;11:543627. doi: 10.3389/fendo.2020.543627. eCollection 2020. |
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| ID | Term |
|---|---|
| D003924 | Diabetes Mellitus, Type 2 |
| D060825 | Cognitive Dysfunction |
| ID | Term |
|---|---|
| D003920 | Diabetes Mellitus |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| ID | Term |
|---|---|
| D026302 | Tai Ji |
| ID | Term |
|---|---|
| D026441 | Mind-Body Therapies |
| D000529 | Complementary Therapies |
| D013812 | Therapeutics |
| D026241 | Exercise Movement Techniques |
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| Peking University | OTHER |
| University of Electronic Science and Technology of China | OTHER |
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|
| Fitness Walking | Behavioral | Participants would take fitness walking training 1 hour/session, 3sessions/week for 24 weeks. There were 10 minutes warm-up, 40 minutes fitness walking and 10 minutes cool-down exercises in the fitness walking training, the exercise intensity was 50% to 70% of the maximum heart rate. Besides, they would also take standard diabetic care education 0.5hour/session, 2 sessions/month for 6 months. |
|
| Standard Diabetic Care Education | Behavioral | Participants would take standard diabetic care education 0.5hour/session, 2 sessions/month for 6 months. |
|
| 24, 36 weeks |
| Digital Symbol test at 24, 36 weeks | Digital Symbol test | 24, 36 weeks |
| Trial Making Test part B at 24, 36 weeks | Trial Making Test part B | 24, 36 weeks |
| Stroop color word test at 24, 36 weeks | Stroop color word test | 24, 36 weeks |
| Boston naming test at 24, 36 weeks | Boston naming test | 24, 36 weeks |
| Rey-Osterrieth complex graphics test at 24, 36 weeks | Rey-Osterrieth complex graphics test | 24, 36 weeks |
| Multi-task balance test: Time up and go test; Time up and go test + cognitive task;Time up and go test + motor task;Time up and go test + cognitive task + motor task at 24, 36 weeks | Time up and go test; Time up and go test + cognitive task (animal naming); Time up and go test + motor task (holding a cup of water); Time up and go test + cognitive task + motor task. | 24, 36 weeks |
| Functional reach test at 24, 36 weeks | Functional reach test | 24, 36 weeks |
| One leg stance test at 24, 36 weeks | One leg stance test | 24, 36 weeks |
| Grip strength at 24, 36 weeks | Grip strength | 24, 36 weeks |
| Five times sit-to-stand test at 24, 36 weeks | Five times sit-to-stand test | 24, 36 weeks |
| Sensation function at 24, 36 weeks | Tactile sensation; Two-point discrimination sensation; Vibration sensation. | 24, 36 weeks |
| Fall efficiency-Modified Falls Efficacy Scale at 24, 36 weeks | Modified Falls Efficacy Scale | 24, 36 weeks |
| Quality of life-Medical Outcomes Study 36-item Short-Form Health Survey at 24, 36 weeks | Medical Outcomes Study 36-item Short-Form Health Survey (SF-36) | 24, 36 weeks |
| 24, 36 weeks |
| Circulating levels of AGE and sRAGE at 24, 36 weeks | Circulating levels of AGE and sRAGE | 24, 36 weeks |
| functional Magnetic Resonance Imaging (fMRI) | functional Magnetic Resonance Imaging | baseline, 24 weeks |
| 33594445 | Background | Guo S, Xu Y, Qin J, Chen Y, You Y, Tao J, Liu Z, Huang J. Effect of tai chi on glycaemic control, lipid metabolism and body composition in adults with type 2 diabetes: A meta-analysis and systematic review. J Rehabil Med. 2021 Mar 22;53(3):jrm00165. doi: 10.2340/16501977-2799. |
| 33706749 | Background | Bai A, Tao L, Huang J, Tao J, Liu J. Effects of physical activity on cognitive function among patients with diabetes in China: a nationally longitudinal study. BMC Public Health. 2021 Mar 11;21(1):481. doi: 10.1186/s12889-021-10537-x. |
| 35002958 | Background | Yin L, Qin J, Chen Y, Xie J, Hong C, Huang J, Xu Y, Liu Z, Tao J. Impact of Body Mass Index on Static Postural Control in Adults With and Without Diabetes: A Cross-Sectional Study. Front Endocrinol (Lausanne). 2021 Dec 24;12:768185. doi: 10.3389/fendo.2021.768185. eCollection 2021. |
| 35859047 | Background | Xie J, Yin L, Huang J, Xu Y, Chen Y, Qin J, Liu Z, Tao J. Correlation between impaired hemodynamic response and cardiopulmonary fitness in middle-aged type 2 diabetes mellitus patients: a case-control study. Eur J Appl Physiol. 2022 Oct;122(10):2295-2303. doi: 10.1007/s00421-022-05008-z. Epub 2022 Jul 20. |
| 37022680 | Derived | Chen Y, Qin J, Tao L, Liu Z, Huang J, Liu W, Xu Y, Tang Q, Liu Y, Chen Z, Chen S, Liang S, Chen C, Xie J, Liu J, Chen L, Tao J. Effects of Tai Chi Chuan on Cognitive Function in Adults 60 Years or Older With Type 2 Diabetes and Mild Cognitive Impairment in China: A Randomized Clinical Trial. JAMA Netw Open. 2023 Apr 3;6(4):e237004. doi: 10.1001/jamanetworkopen.2023.7004. |
| D004700 | Endocrine System Diseases |
| D003072 | Cognition Disorders |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
| D026741 |
| Physical Therapy Modalities |