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This is a multicenter prospective study that aims to investigate the clinical impact of SARS-CoV-2 infection in pregnant women, pregnancy outcomes and perinatal transmission.
This is a cohort study of pregnant women confirmed positive for SARS-CoV-2 infection. Data will be collected in Portuguese maternities that agreed to collaborate in this study.
Pregnant women are tested during hospital admission by using nasopharyngeal/oral swabs for SARS-CoV-2 RT PCR as part of a universal testing policy. Maternal demographic data (age, comorbidities, parity, smoking habits), COVID-19 related data (symptoms, diagnostic tests, therapy used and ICU admission), gestational age at SARS-CoV-2 confirmed infection, pregnancy outcomes (gestational complications, gestational age at birth, mode of delivery) and neonatal outcome (birthweight and Apgar score, RT PCR neonate results) and breastfeeding strategies will be evaluated.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| RT PCR SARS-CoV-2 | Diagnostic Test | Positive SARS-CoV-2 RT PCR in nasopharyngeal/oral swab tests or presence of IgM in blood samples |
|
| Measure | Description | Time Frame |
|---|---|---|
| SARS-CoV-2 Neonatal Infection | Positive Sars-Cov-2 RT PCR in nasopharyngeal/oral swab tests or presence of IgM in blood samples | 7 days |
| Measure | Description | Time Frame |
|---|---|---|
| Perinatal mortality | stillbirths and deaths in the first week of life | 35 weeks |
| ICU maternal admission | maternal ICU admission due to COVID-19 |
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Inclusion Criteria: Pregnant women infected with Sars-Cov-2. Delivery at Portuguese maternities.
Exclusion Criteria: RT PCR SARS-CoV-2 negative.
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Pregnant women infected with Sars-Cov-2 from 6 to 41 weeks.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Nadia Charepe, MD,MSc | Contact | 00351213184000 | nadia.charepe@chlc.min-saude.pt | |
| Alexandra Queirós, MD | Contact | 00351213184000 | alexandra.queiros@nms.unl.pt |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Nova Medical School - UNL | Recruiting | Lisbon | Portugal |
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| ID | Term |
|---|---|
| D018352 | Coronavirus Infections |
| D011248 | Pregnancy Complications |
| D001942 | Breast Feeding |
| ID | Term |
|---|---|
| D003333 | Coronaviridae Infections |
| D030341 | Nidovirales Infections |
| D012327 | RNA Virus Infections |
| D014777 | Virus Diseases |
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| ID | Term |
|---|---|
| D000087123 | COVID-19 Nucleic Acid Testing |
| ID | Term |
|---|---|
| D000086742 | COVID-19 Testing |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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| 35 weeks |
| 5 minute Apgar Score < 7 | Newborn 5 minute Apgar Score < 7 | 1 day |
| Preterm labour | Delivery between 24 and 36 weeks | 35 weeks |
| PPROM | Preterm premature rupture of the membranes between 24 and 36 weeks | 35 weeks |
| Miscarriage | spontaneous pregnancy loss before 24 weeks | 14 weeks |
| D007239 |
| Infections |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D005247 | Feeding Behavior |
| D001519 | Behavior |
| D008919 | Investigative Techniques |