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The aim of this study will be to analyze the newly formed bone volume and density, 6 months after alveolar cleft grafting using iliac cancellous bone graft, with and without bone marrow concentrate.
Twelve patients with unilateral alveolar cleft will be enrolled in this randomized comparative study.
The patients will be divided into two groups, the control (group A) who received illiac cancellous bone graft and study group who received a combination of bone marrow concentrate and illiac cancellous bone graft (group B).
Cone Beam CT (CBCT) images will be done prior to surgery to asses preoperative alveolar defect volume. Six months postoperative CBCT images will be done and postoperative newly bone formed volume and density will be evaluated and bone formation ratio (BF%) will be calculated as follows: BF% = (formed volume/alveolar defect) × 100%.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Bone marrow concentrate | Experimental | Bone marrow concentrate combined with Autogenous bone graft |
|
| autogenous bone graft | Active Comparator | grafting with autogenous bone graft |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| bone marrow concentrate alveolar cleft grafting | Procedure | patients will undergo surgery to repair alveolar cleft with autogenous bone graft combined with bone marrow concentrate |
| Measure | Description | Time Frame |
|---|---|---|
| bone volume | V= (A1xT) + ( A2 xT) + …….+ (An xT) where: V= volume A= area T= thickness of the axial C.T slice N=number of slices | six months postoperative |
| Measure | Description | Time Frame |
|---|---|---|
| bone density | the average bone density will be measured from the CBCT | six months postoperative |
| bone formation ratio | BF% = (formed volume/alveolar defect) × 100%. |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Faculty of Dentistry | Al Fayyum | 63514 | Egypt | |||
| Faculty of Dentistry |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 32446283 | Background | Pinheiro FHSL, Drummond RJ, Frota CM, Bartzela TN, Dos Santos PB. Comparison of early and conventional autogenous secondary alveolar bone graft in children with cleft lip and palate: A systematic review. Orthod Craniofac Res. 2020 Nov;23(4):385-397. doi: 10.1111/ocr.12394. Epub 2020 Jun 28. | |
| 31034242 | Background |
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Eighteen patients will be divided into two equal groups. Each group comprises nine patients.
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| Autogenous alveolar grafting | Procedure | patients will undergo surgery to repair alveolar cleft with autogenous bone graft |
|
| six months postoperative |
| Cairo |
| 21523 |
| Egypt |
| Ziegler CG, Van Sloun R, Gonzalez S, Whitney KE, DePhillipo NN, Kennedy MI, Dornan GJ, Evans TA, Huard J, LaPrade RF. Characterization of Growth Factors, Cytokines, and Chemokines in Bone Marrow Concentrate and Platelet-Rich Plasma: A Prospective Analysis. Am J Sports Med. 2019 Jul;47(9):2174-2187. doi: 10.1177/0363546519832003. Epub 2019 Apr 29. |
| 37794139 | Derived | Shabaan AA, Salahuddin A, Aboulmagd I, Ragab R, Salah KA, Rashid A, Ayad HM, El Aty Ahmed WA, Refahee SM. Alveolar cleft reconstruction using bone marrow aspirate concentrate and iliac cancellous bone: A 12-month randomized clinical study. Clin Oral Investig. 2023 Nov;27(11):6667-6675. doi: 10.1007/s00784-023-05276-9. Epub 2023 Oct 5. |