Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The performance of the microbiota is observed in all clinical and pathological stages of carcinogenesis, since its development, diagnosis and treatment, including prognosis and survival. However, it was found that there is a scarcity of studies on biliary microbiota and its relationship with hepatobiliopancreatic diseases. Therefore, further investigation is necessary, since reaching the biliary microbiota may suggest ways for studies of biomarkers, diagnoses, tests and therapies in hepatobiliopancreatic diseases. For this, bile samples will be collected in cases and controls patients to characterize the microbiota and its variations according to the disease.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients who will undergo ERCP (case group) | |||
| Living liver transplantation donors (control group) |
Not provided
| Measure | Description | Time Frame |
|---|---|---|
| Composition of the biliary microbiota | In this study, the investigator's objective will be to characterize the specific composition of the biliary microbiota in patients with hepatobiliopancreatic diseases in comparison with healthy people using 16S ribosomal RNA (rRNA) pyrosequencing methods. | 2 years |
Not provided
Not provided
Inclusion Criteria:
Endoscopic retrograde cholangiopancreatography (ERCP) candidates (case group)
Liver transplant living-donor (control group)
Exclusion Criteria:
ERCP candidates (case group)
Liver transplant living-donor (control group)
Not provided
Not provided
Not provided
Tertiary care adult patients with hepatobiliopancreatic diseases compared to healthy people, that are living donors of liver transplant
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Alberto Meyer, PhD | Contact | +55(11)2661-3323 | alberto.meyer@usp.br |
Not provided
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Sao Paulo School of Medicine | Recruiting | São Paulo | 05403-000 | Brazil |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33211762 | Derived | Nascimento FSD, Suzuki MO, Taba JV, de Mattos VC, Pipek LZ, D'Albuquerque EMC, Iuamoto L, Meyer A, Andraus W, Pinho JRR, de Moura EGH, Setubal JC, Carneiro-D'Albuquerque LA. Analysis of biliary MICRObiota in hepatoBILIOpancreatic diseases compared to healthy people [MICROBILIO]: Study protocol. PLoS One. 2020 Nov 19;15(11):e0242553. doi: 10.1371/journal.pone.0242553. eCollection 2020. |
Not provided
Not provided
Not provided
| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot | Yes | No | No | Study Protocol | Jun 4, 2020 | Jun 10, 2020 | Prot_002.pdf |
| ICF | No | No | Yes | Informed Consent Form | Mar 19, 2020 | Apr 28, 2020 | ICF_001.pdf |
Not provided
| ID | Term |
|---|---|
| D010182 | Pancreatic Diseases |
| D064806 | Dysbiosis |
| D001660 | Biliary Tract Diseases |
| ID | Term |
|---|---|
| D004066 | Digestive System Diseases |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
Not provided
Not provided
Not provided
Not provided
Not provided