Challenges in recruiting participants.

The purpose of this research is to test an investigational drug called Adipose Mesenchymal Stem Cells (aMSCs) for the treatment of ischemia re-perfusion injury (IRI) in patients that have had a kidney transplant.

Inclusion Criteria:

• Male or female kidney transplant candidates age 18 and above.
• Patient is receiving kidney allograft from deceased donor with KDPI>85%.
• Ability of subject to give appropriate consent.
• Females of childbearing potential with agreement to use birth control for six months post-transplant.
• Approved by the Mayo Clinic Transplant Selection Committee.
• Signed Authorization for Donation of Anatomical Gifts on file.

Exclusion Criteria:

• Positive pregnancy test at the time of the kidney offer is called for the potential recipient.
• Kidney transplant potential recipients with active malignancy (except none melanoma skin malignancies).
• Patients with previous history of solid organ transplant (Heart, Lung, Intestine, Kidney and/or Pancreas).
• Patients with previous history of bone marrow transplant.