A 12-month pilot study will be comprised of two groups of people diagnosed with mild Alzheimer's disease and related dementia for a total of 80 senior subjects. Subjects will be randomly assigned to two groups: Group 1 users will play games with and administered by Ryan, 2-3 times a week and 30-minutes per day. Group 2 (Active Control Group) will play solitary games and activities but will have to interaction with Ryan. The team will measure the changes and improvement in the social/emotional well-being of these two groups and eventual changes in the cognitive/memory functions of elderly people living in the similar environment.

Inclusion Criteria

• Age ≥ 65 years
• Early Alzheimer's disease and related dementia diagnosed by a qualified provider
• Saint Louis University Mental Status (SLUMS) score between 10 and 25
• Resident of assisted living facility for at least one month prior and for the duration of the study
• Deemed conditioned enough to participate in physical activities after a wellness check
• Verbal skill to interact
• Participant or Legal decision

Exclusion Criteria:

Aggressive behavior

• Diagnosed with severe dementia or memory loss
• Acute physical illness that impairs ability to participate
• Patients with serious comorbidity, tumors and other diseases casually related to cognitive impairment
• History of alcohol or drug abuse, head trauma, psychoactive substance use and other causes of memory impairment
• Significant sensory impairment

The adverse events were monitored and assessed at the participant level (up to 10 weeks) throughout the study. As a result, no adverse events were reported during the study period.

No adverse event was reported.

The study was conducted right after COVID-19 restrictions were lifted. The main limitation was that some potential subjects had medical constraints or concerns and did not want to participate. Additionally, poor internet connections in some senior care facilities limited the ability to converse with the robot.