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The aim of this study is to determine the risk factors for development of ventilator-associated pneumonia (VAP) and to identify the prognostic factors of VAP among Coronavirus Disease 2019 (CoViD-19) patients. We hypothesized that CoViD-19 serves as a high risk factor for the development of VAP and it affects clinical outcome measures negatively.
Coronavirus Disease 2019 (CoViD-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) became a pandemic affecting thousands of individuals worldwide. A considerable proportion of CoViD-19 patients require admission to the intensive care unit (ICU), although limited data are available on their clinical characteristics and course. The results of retrospective studies indicate older age, presence of comorbidies and secondary infections as predictors of mortality among this population. Further evaluation regarding ICU clinical course and predictors of mortality is needed.
The aim of this study is to determine the risk factors for development of VAP and to identify the prognostic factors of VAP among CoViD-19 patients.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Assessment of ventilator-associated pneumonia criteria | Diagnostic Test | Diagnosis of ventilator-associated pneumonia is based upon the routine daily clinical and laboratory parameters. |
| Measure | Description | Time Frame |
|---|---|---|
| 28-day all-cause mortality | at study completion, anticipated 5 months |
| Measure | Description | Time Frame |
|---|---|---|
| Days of mechanical ventilation | average time frame expected 2-3 weeks | |
| ICU length-of-stay | average time frame expected 3-4 weeks | |
| Antibiotic utilization |
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Inclusion Criteria:
Exclusion Criteria:
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Critically ill individuals diagnosed with PCR confirmed CoViD-19 disease requiring mechanical ventilation for > 48 hours.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Semmelweis University | Recruiting | Budapest | 1085 | Hungary |
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| ID | Term |
|---|---|
| D053717 | Pneumonia, Ventilator-Associated |
| D018352 | Coronavirus Infections |
| ID | Term |
|---|---|
| D000077299 | Healthcare-Associated Pneumonia |
| D003428 | Cross Infection |
| D007239 | Infections |
| D011014 | Pneumonia |
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| average time frame expected 3-4 weeks (at discharge from ICU) |
| Ventilator-associated pneumonia rate | at study completion, anticipated 5 months |
| D012141 |
| Respiratory Tract Infections |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D007049 | Iatrogenic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D003333 | Coronaviridae Infections |
| D030341 | Nidovirales Infections |
| D012327 | RNA Virus Infections |
| D014777 | Virus Diseases |