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Muscle relaxant is usually needed for surgery. However, the optimal depth of neuro-muscular blockade is still on debate. Deep neuro-muscular blockade may benefit the patients during surgery, but may increase the risk of residual blockade after surgery. Residual blockade has been reported to increase risk of morbidity. In this study, we tend to observe the postoperative outcomes in patients undergoing abdominal surgery under general anesthesia. And to compare the outcomes in patients received different depth of neuro-muscular blockade.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Deep neuro-muscular blockade |
| ||
| Moderate neuro-muscular blockade |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| No Response to Train of Four Stimulation | Other | No response is observed during Train of Four stimulation monitoring during surgery |
|
| Measure | Description | Time Frame |
|---|---|---|
| Visual Analogue Scale of pain at rest at 24 hours after surgery | The intensity of pain is reported by the patient by provide a number between 0 and 10. 0 means no pain, and 10 means unbearable pain. Higher score means stronger pain. | from end of surgery to 24 hours after surgery |
| Visual Analogue Scale of pain at cough at 24 hours after surgery | The intensity of pain is reported by the patient by provide a number between 0 and 10. 0 means no pain, and 10 means unbearable pain. Higher score means stronger pain. | from end of surgery to 24 hours after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of patients suffering pain at 24 hours after surgery | from end of surgery to 24 hours after surgery | |
| Time to flatus | from end of surgery to flatus, on an average of 3 days | |
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Inclusion Criteria:
Exclusion Criteria:
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Patients scheduled for laparoscopic surgery are consecutively screened with inclusion and exclusion criteria.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| First hospital of Beijing University | Beijing | Beijing Municipality | China | |||
| Xiehe Hospital of Fujian Medical University |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 26479510 | Background | Madsen MV, Istre O, Staehr-Rye AK, Springborg HH, Rosenberg J, Lund J, Gatke MR. Postoperative shoulder pain after laparoscopic hysterectomy with deep neuromuscular blockade and low-pressure pneumoperitoneum: A randomised controlled trial. Eur J Anaesthesiol. 2016 May;33(5):341-7. doi: 10.1097/EJA.0000000000000360. | |
| 27936214 | Background |
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| ID | Term |
|---|---|
| D011183 | Postoperative Complications |
| D009123 | Muscle Hypotonia |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D020879 | Neuromuscular Manifestations |
| D009461 | Neurologic Manifestations |
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| 1-2 Response to Train of Four Stimulation | Other | 1 to 2 response is observed during Train of Four stimulation monitoring during surgery |
|
| Time to extubation of the endotracheal tube |
| from end of surgery to removal of the endotracheal tube, on an average of 15 minutes |
| Incidence of major postoperative complications | Incidence of major postoperative complications (including myocardial ischemia, pulmonary infection, respiratory failure, brain ischemia) | from end of surgery to discharge from the hospital, on an average of 5 days |
| Satisfaction score of the Surgeon to the condition during surgery | The satisfaction of the Surgeon is measured by a scale from 0-10. 0 is for extremely unsatisfied, 10 is for totally satisfied. Higher score means higher satisfaction. The surgeon is asked to give a number between 0 and 10 to describe his satisfaction. | from start of surgery to end of surgery, on an average of 2.5 hours |
| Fuzhou |
| Fujian |
| China |
| First Afiliated Hospital of Zhengzhou University | Zhengzhou | Henan | 450052 | China |
| Tongji Hospital of Tongji Medical School | Wuhan | Hubei | China |
| Xiehe Hospital of Tongji Medical School | Wuhan | Hubei | China |
| Ruijin Hospital | Shanghai | Shanghai Municipality | China |
| Huaxi Hospital | Chengdu | Sichuan | China |
| General hospital of Tianjin Medical University | Tianjin | Tianjin Municipality | China |
| People's Hospital of Jiangsu | Nanjing | China |
| Torensma B, Martini CH, Boon M, Olofsen E, In 't Veld B, Liem RS, Knook MT, Swank DJ, Dahan A. Deep Neuromuscular Block Improves Surgical Conditions during Bariatric Surgery and Reduces Postoperative Pain: A Randomized Double Blind Controlled Trial. PLoS One. 2016 Dec 9;11(12):e0167907. doi: 10.1371/journal.pone.0167907. eCollection 2016. |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |