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| Name | Class |
|---|---|
| Cardiovascular Centre of Universidade de Lisboa (CCUL) | UNKNOWN |
| Faculty of Medicine of Universidade de Lisboa (FMUL) | UNKNOWN |
| Centro Hospitalar Universitário Lisboa Norte | OTHER |
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Vitamin D deficiency has been linked to hypertension, autoimmune, infectious and cardiovascular diseases which are risk factors for COVID-19. Moreover, COVID-19 patients have a very high prevalence of hypovitaminosis D (Turin data). Taken together, we aim to investigate whether genetic variants in vitamin D-related genes contribute to a poor COVID-19 outcome, particularly in hypertension and CV patients, proposing thus a personalized therapeutics based on vitamin D supplementation in order to reduce the severity and deaths.
Collected data from Turin University indicate that hospitalized patients have a very high prevalence of hypovitaminosis D. Reports from China and Italy show that hypertension presents an increased risk of COVID-19-related death. Otherwise, observational studies suggest that 25(OH)D induces protection against respiratory pathogens while large-scale studies indicate that serum 25(OH)D-level is inversely correlated to hypertension prevalence. Recent published data (2020) shows that 66% of Portuguese adults present Vitamin D deficiency. HeartGenetics' genetic database with more than 8.500 Portuguese genotypes shows that the prevalence of vitamin D polymorphisms in this population is 4-fold higher than the EU average, increasing the risk of hypovitaminosis D.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Mild to severe disease | Mild to severe disease (admission to isolation room) |
| |
| Critical patients | Critical patients (admission to ICU) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Exposure | Other | Individuals with SARS-CoV-2 exposure and COVID-19 symptoms. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Differences in vitamin D blood levels between COVID-19 patients with different degrees of disease severity. | Blood samples of COVID-19 patients will be collected at baseline (after subject enrollment; single point collection). | |
| Differences in genetic variants in vitamin D-related genes between COVID-19 patients with different degrees of disease severity. | Blood samples of COVID-19 patients will be collected at baseline (after subject enrollment; single point collection). |
| Measure | Description | Time Frame |
|---|---|---|
| Differences in vitamin D blood levels between COVID-19 patients in relation to mortality. | Through study completion, an average of 3 months. | |
| Differences in vitamin D blood levels between COVID-19 patients in relation to length of stay in hospitals. | Through study completion, an average of 3 months. |
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Inclusion Criteria:
Exclusion Criteria:
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COVID-19 patients admitted to hospitals from Lisbon and Oporto.
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| Name | Affiliation | Role |
|---|---|---|
| Fausto J Pinto, PhD | Faculty of Medicine of Universidade de Lisboa | Principal Investigator |
| Conceição Calhau, PhD | Universidade Nova de Lisboa | Principal Investigator |
| Ana Freitas, PhD | HeartGenetics SA | Principal Investigator |
| Tiago Guimarães, PhD | Universidade do Porto | Principal Investigator |
| Ana Melo, PhD | BioData.pt/Instituto Gulbenkian Ciência | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cardiovascular Center at Universidade de Lisboa | Lisbon | Lisbon District | 1649-032 | Portugal | ||
| Centro Hospitalar Universitário Lisboa Norte |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34675344 | Derived | Freitas AT, Calhau C, Antunes G, Araujo B, Bandeira M, Barreira S, Bazenga F, Braz S, Caldeira D, Santos SCR, Faria A, Faria D, Fraga M, Nogueira-Garcia B, Goncalves L, Kovalchuk P, Lacerda L, Lopes H, Luis D, Medeiros F, Melo AMP, Melo-Cristino J, Miranda A, Pereira C, Pinto AT, Pinto J, Proenca H, Ramos A, Rato JPR, Rocha F, Rocha JC, Moreira-Rosario A, Vazao H, Volovetska Y, Guimaraes JT, Pinto FJ. Vitamin D-related polymorphisms and vitamin D levels as risk biomarkers of COVID-19 disease severity. Sci Rep. 2021 Oct 21;11(1):20837. doi: 10.1038/s41598-021-99952-z. |
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| ID | Term |
|---|---|
| D000086382 | COVID-19 |
| ID | Term |
|---|---|
| D011024 | Pneumonia, Viral |
| D011014 | Pneumonia |
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
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| Centro Hospitalar De São João, E.P.E. |
| OTHER |
| CINTESIS - Center for Health Technology and Services Research | UNKNOWN |
| Universidade Nova de Lisboa | OTHER |
| HeartGenetics, Genetics and Biotechnology SA | INDUSTRY |
| Instituto Gulbenkian de Ciência (IGC) | UNKNOWN |
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| Differences in vitamin D blood levels between COVID-19 patients in relation to duration of mechanical ventilation. | Through study completion, an average of 3 months. |
| Differences in genetic variants in vitamin D-related genes between COVID-19 patients in relation to mortality. | Through study completion, an average of 3 months. |
| Differences in genetic variants in vitamin D-related genes between COVID-19 patients in relation to length of stay in hospitals. | Through study completion, an average of 1 year. |
| Differences in genetic variants in vitamin D-related genes between COVID-19 patients in relation to duration of mechanical ventilation. | Through study completion, an average of 3 months. |
| Lisbon |
| Lisbon District |
| 1649-032 |
| Portugal |
| Centro Hospitalar de São João | Porto | 4200-319 | Portugal |
| D014777 |
| Virus Diseases |
| D018352 | Coronavirus Infections |
| D003333 | Coronaviridae Infections |
| D030341 | Nidovirales Infections |
| D012327 | RNA Virus Infections |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |