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To study the effects of a low free sugar diet on lipid profile, glycemic indices, liver enzymes, inflammatory factors and hepatic steatosis and fibrosis in patients with Nonalcoholic fatty liver disease, 50 patients who referred to Gastrointestinal (GI) clinic with steatosis grade 2 and 3 will be randomly allocated to receive low free sugar diet or regular diet for 12 weeks; both groups will be advised to adherence the investigators' nutrition recommendation and exercise program too. At the first and the end of the intervention, lipid profiles, liver enzymes,glycemic indices, some inflammatory markers, and liver fibrosis will be assessed and compared between groups.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Intervention | Experimental | low free sugar diet with nutrition and exercise recommendation |
|
| control | No Intervention | regular diet with nutrition and exercise recommendation |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| low free sugar diet | Other | low free sugar diet with nutrition and exercise recommendation |
|
| Measure | Description | Time Frame |
|---|---|---|
| ALT | serum level of Alanine transaminase | 12 weeks |
| AST | serum level of Aspartate transaminase | 12 weeks |
| GGT | serum level of Gamma glutaminase | 12 weeks |
| TG | serum level of Triglyceride | 12 weeks |
| Total cholesterol | serum level of total cholesterol | 12 weeks |
| LDL-c | serum level of LDL-Cholesterol | 12 weeks |
| HDL-c | serum level of HDL-Cholesterol | 12 weeks |
| FBS | serum level of Fasting blood sugar | 12 weeks |
| Insulin | serum level of Insulin | 12 weeks |
| hs-CRP |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Azita Hekmatdoost, MD,PhD | Contact | +989123065084 | a_hekmat2000@yahoo.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Azita Hekmatdoost | Recruiting | Tehran | Middle East | 19835 | Iran |
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| ID | Term |
|---|---|
| D065626 | Non-alcoholic Fatty Liver Disease |
| ID | Term |
|---|---|
| D005234 | Fatty Liver |
| D008107 | Liver Diseases |
| D004066 | Digestive System Diseases |
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Serum level of high-sensitive C-reactive protein
| 12 weeks |
| TNF-a | Serum level of Tumor necrosis factor-a | 12 weeks |
| NF-kb | Activity of Nuclear factor-B in peripheral monocellular cells | 12 weeks |
| Liver fibrosis | Liver fibrosis according to fibroscan exam | 12 weeks |
| National Nutrition and Food Technology Research Institute | Recruiting | Tehran | Iran |
|