DSA Risk Factors in MMF-based Immunosuppressed Post-transplanted Patients

DSA Risk Factors in Chinese Kidney Transplant Patients Using MPA-based Immunosuppression Protocol: A Multi-center Clinical Study

Kidney transplantation is the best therapy method for patients with uremia. The main factors affecting the long-term survival of the graft were chronic antibody-mediated rejection and the death of the patients. Newborn donor special antibody (DSA) is a major risk factor for chronic antibody-mediated rejection (AMR) and poor transplantation outcomes. Detection of mycophenolate mofetil (MMF) trough concentration can help estimate its exposure. Deficient exposure of MMF can lead to AMR after transplantation surgery. The aim of this study is to estimate the risk factors of one-year DSA after transplantation.

Inclusion Criteria:

• years 18-65
• single organ transplantation
• first time to accept kidney transplantation
• Triple immunosuppression protocol based on MMF, tacrolimus and glucocorticoid
• PRA negative before transplantation
• not pregnant for female

Exclusion Criteria:

• Not accept MMF
• multi-organ transplantation
• pregnancy or lactation period female
• mental illness
• past tumor, peptic ulcer, severe cardiopulmonary disease, active liver disease history
• Cannot regular follow up