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The investigators hypothesize that those with respiratory failure due to COVID-19 will have different burdens of mental and physical disability than those with respiratory failure who do not have COVID-19. Detecting these potential differences will lay an important foundation for treating long term sequelae of respiratory failure in these two cohorts.
The aim of this proposal to is to understand the extent and degree of physical disability, psychological sequelae, and cognitive dysfunction survivors of COVID-19 related critical illness will have upon hospital discharge, 6 months, and up to one year post discharge. These outcomes of interest will be evaluated prospectively. The investigators will perform these measures in Covid-19 patients with respiratory failure and compare them to non-Covid-19 patients with respiratory failure. The investigators also seek to determine the risk factors of these long-term complications in order to guide providers as to which patients should be screened for these deficits. Finally, the investigators will examine the association of various critical care interventions such as invasive versus noninvasive mechanical ventilation or use of sedatives and their effects on disability and cognitive dysfunction.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| COVID19 positive | ICU patients coronavirus positive |
| |
| non-COVID19 | ICU patients without coronavirus |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Quality of Life | Other | Physical disability assessment tool |
|
| Measure | Description | Time Frame |
|---|---|---|
| Quality of Life score | SF-36 score | up to 12 months after discharge |
| Measure | Description | Time Frame |
|---|---|---|
| cognitive dysfunction | Montreal Cognitive Assessment (MoCA) score | up to 12 months after discharge |
| Functional Status Score | (FSS-ICU) |
| Measure | Description | Time Frame |
|---|---|---|
| hospital anxiety and depression | hospital anxiety and depression scale | up to 12 months after discharge |
| ICU related complications | including ventilator associated pneumonia, GI hemorrhage, Deep Vein Thrombosis (DVT) /Pulmonary Embolus (PE), sacral decubitus ulcer, delirium, ICU acquired weakness |
Inclusion Criteria:
Exclusion Criteria:
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adult patients admitted to the intensive care unit
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Chicago Medical Center | Chicago | Illinois | 60637 | United States |
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| ID | Term |
|---|---|
| D016638 | Critical Illness |
| D018352 | Coronavirus Infections |
| D012131 | Respiratory Insufficiency |
| D000086382 | COVID-19 |
| ID | Term |
|---|---|
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D003333 | Coronaviridae Infections |
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| ID | Term |
|---|---|
| D011788 | Quality of Life |
| C018209 | 4-amino-4'-hydroxylaminodiphenylsulfone |
| ID | Term |
|---|---|
| D006304 | Health Status |
| D003710 | Demography |
| D015991 | Epidemiologic Measurements |
| D011634 | Public Health |
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| Impact Event Score | Other | Psychological Sequelae assessment tool |
|
|
| Hospital anxiety and depression scale | Other | Psychological Sequelae assessment tool |
|
| up to 12 months after discharge |
| Physical Disability | MRC neuromuscular Assessment | up to 12 months after discharge |
| Psychological Sequelae | Impact Event Score | up to 12 months after discharge |
| hospitalization up to 6 weeks |
| hospital discharge location | measure the location (home, rehabilitation center, nursing home | hospital discharge up to 6 weeks |
| lCU length of stay | number of days admitted to the ICU | hospitalization up to 6 weeks |
| hospital length of stay | number of days admitted to the hospital | hospitalization up to 6 weeks |
| D030341 | Nidovirales Infections |
| D012327 | RNA Virus Infections |
| D014777 | Virus Diseases |
| D007239 | Infections |
| D012120 | Respiration Disorders |
| D012140 | Respiratory Tract Diseases |
| D011024 | Pneumonia, Viral |
| D011014 | Pneumonia |
| D012141 | Respiratory Tract Infections |
| D008171 | Lung Diseases |
| D004778 |
| Environment and Public Health |