Different PEEP Settings of COVID-19 Induced ARDS

Avoiding High PEEP in COVID-19 Induced ARDS: a Multi-center Study

This was a multi-center prospective study. All consecutive severe cases of COVID-19 whose PO2/FiO2<300mmHg with invasive ventilation admitted to 5 fixed-point receive COVID-19 patients hospitals in Wuhan from 5 March to 15 March 2020 were included. Epidemiological, clinical data, lung mechanics, artery blood gas test and hemodynamics at three methods to titrate PEEP, optimizing oxygenation, optimizing compliance, ARDSnet. The study was approved by the Ethics Committee of Zhongda Hsopital, Southeast University.

After PEEP titration, PEEP settings could be set by optimizing oxygenation, optimizing compliance, ARDSnet.

Inclusion Criteria:

• COVID-19 patients with mechanical ventilation
• PO2/FIO2<300mmHg
• ages>18 years

Exclusion Criteria:

• pneumothorax
• pregnant
• hemodynamics is unstable