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This was a multi-center prospective study. All consecutive severe cases of COVID-19 whose PO2/FiO2<300mmHg with invasive ventilation admitted to 5 fixed-point receive COVID-19 patients hospitals in Wuhan from 5 March to 15 March 2020 were included. Epidemiological, clinical data, lung mechanics, artery blood gas test and hemodynamics at three methods to titrate PEEP, optimizing oxygenation, optimizing compliance, ARDSnet. The study was approved by the Ethics Committee of Zhongda Hsopital, Southeast University.
After PEEP titration, PEEP settings could be set by optimizing oxygenation, optimizing compliance, ARDSnet.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Optimizing oxygenation | Experimental | Best oxygenation during PEEP titration |
|
| Optimizing compliance | Experimental | Best compliance during PEEP titration |
|
| ARDSnet | Experimental | PEEP settings according to ARDSnet table |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Gas exchanges at different PEEP | Other | Gas exchanges measurement at different PEEP |
|
| Measure | Description | Time Frame |
|---|---|---|
| Respiratory system compliance improvement | the respiratory system compliance was compared among three groups | 20 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| Gas echanges improvement | P/Fwere compared among three groups | 20 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| hemodynamics improvement | MAP were compared among three groups | 20 minutes |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Chun C Pan | Zhongda hospital, Southeast University, Jiangsu, China | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Zhongda Hospital, Southeast University | Nanjing | Jiangsu | 210009 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34355001 | Derived | Pan C, Lu C, She X, Ren H, Wei H, Xu L, Huang Y, Xia J, Yu Y, Chen L, Du B, Qiu H. Evaluation of Positive End-Expiratory Pressure Strategies in Patients With Coronavirus Disease 2019-Induced Acute Respiratory Distress Syndrome. Front Med (Lausanne). 2021 Jul 20;8:637747. doi: 10.3389/fmed.2021.637747. eCollection 2021. |
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| ID | Term |
|---|---|
| D000086382 | COVID-19 |
| D012128 | Respiratory Distress Syndrome |
| ID | Term |
|---|---|
| D011024 | Pneumonia, Viral |
| D011014 | Pneumonia |
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
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| lung mechanics at different PEEP | Other | lung mechanics measurement at different PEEP |
|
| Hemodynamics changes at different PEEP | Other | Hemodynamics changes measurement at different PEEP |
|
| D014777 |
| Virus Diseases |
| D018352 | Coronavirus Infections |
| D003333 | Coronaviridae Infections |
| D030341 | Nidovirales Infections |
| D012327 | RNA Virus Infections |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D012120 | Respiration Disorders |