Clinical pharmacy is a patient-centered discipline and improves significantly the safety of drug management. Regarding medications, clinical pharmacy is efficient. The investigator hypothesize that clinical pharmacy applied to medical devices could be as effective as in the medication field.

The main objective of this study is to assess the effectiveness of clinical pharmacy activities during entire care pathways of patients implanted with a PICC line, in preventing complications.

This is a preliminary, before-after, monocentric and prospective study. The study will begin with an observational period and will be followed by an experimental intervention period. Sixty-nine adult patients in each period will be included. During the observational phase, no clinical pharmacy activities will be performed. During the interventional phase, clinical pharmacists will be active during the entire patients' care pathways.

Inclusion Criteria:

• Adult patient, age equal to or older than 18 years old
• Patient capable of giving free and informed consent
• Patient insured by the Social Security System
• Patient living at home
• Patient with a PICC line prescription
• Patient whose discharge prescription should contain drugs and MDs
• Patient for home discharge implanted with a PICC line
• Patient reachable by phone

Exclusion Criteria:

• Under aged patient, age under 18 years old
• Uninsured patient by the Social Security System
• Patient not living at home :
• Institutionalized patient
• Patient living in a home for elderly dependent persons
• Nursing home resident
• Home-hospitalized patient
• Patient deprived of liberty by a judicial or administrative decision
• Patient under guardianship, curatorship or safeguard of justice
• Patient unreachable by phone
• Pregnant or breastfeeding women