The purpose of this study is to determine the rate and timing of interventions and complications related to the use of peripherally inserted central venous catheters in adult patients.

Inclusion Criteria:

• Male or Female Age > 18 years requiring central venous access
• Ability to comply with study requirements
• Written Informed Consent

Exclusion Criteria:

• Previous enrollment in study
• Current or recent upper extremity thrombosis, occlusion or stenosis
• Previous axillary lymph node dissection
• Skin inflammatory condition or rashes within 15 cm from insertion site
• Pre-existing history of hypercoagulability unrelated to malignant disease
• Participating in trial involving antithrombotic, anticoagulant or anti- infective drug therapies
• Positive blood culture within 48 hours from planned PICC placement
• Known, renal insufficiency with chronic creatinine levels > 1.7 mg/dl

Adult patients necessitating insertion of a PICC for fluid, nutritional, chemotherapy or antibiotic treatment for a minimum of 14 days.

This observationaol study included recording of line occlusions and incidence of venous thrombosis from the time of PICC insertion until removal of the PICC line or for a maximum of 90 days.

Further comparative studies standarizing the management of PICC line flushing solutions and type if PICC line required to provide comparative and evidence based clinical practice recommendations.