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The investigators conduct the real world study to explore mechanisms of autism based on multi-modal data.
Children with autism spectrum disorder registered in Xinhua Hospital are measured in aspects of behavioural accessment, genetic test, blood lab test, gut microbiome and neuroimaging including structural and functional magnetic resonance imaging (MRI), functional near - infrared spectroscopy(f-NIRS), electroencephalography and eye movement. The investigators conduct the real world study to explore mechanisms of autism based on the multi-modal data.
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| Measure | Description | Time Frame |
|---|---|---|
| Behaviour assessment | The behaviour development of participants includes intellectual/developmental quotient, syptoms severity, comorbidity, etc. | The baseline and 3 months |
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| Measure | Description | Time Frame |
|---|---|---|
| Genetic characteristics | Genome wide association study from blood sample | The baseline |
| Blood test | Retained blood samples tested in immunomics, metabonomics, etc |
Inclusion Criteria:
Exclusion Criteria:
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Children with autism spectrum disorder have registered in Xinhua hospital and provided written informed consent from themselves and/or their legal guardians.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Fei Li, doctor | Contact | +86-21-25077461 | feili@shsmu.edu.cn |
| Name | Affiliation | Role |
|---|---|---|
| Fei Li, doctor | Xinhua hospital Affilated to Shanghai Jiao Tong University School of Medicine | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| ShanghaiXinhua | Recruiting | Shanghai | Shanghai Municipality | 200092 | China |
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| ID | Term |
|---|---|
| D000067877 | Autism Spectrum Disorder |
| ID | Term |
|---|---|
| D002659 | Child Development Disorders, Pervasive |
| D065886 | Neurodevelopmental Disorders |
| D001523 | Mental Disorders |
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Blood and stool samples are retained in Xinhua
| The baseline and 3 months |
| Blood test | Retained blood samples tested in immunomics, metabonomics, etc | The baseline and 6 months |
| Blood test | Retained blood samples tested in immunomics, metabonomics, etc | The baseline and 12 months |
| Gut mircobiome | Retained stool samples tested in metabonomics, genomics, etc | The baseline and 1 months |
| Gut mircobiome | Retained stool samples tested in metabonomics, genomics, etc | The baseline and 3 months |
| Gut mircobiome | Retained stool samples tested in metabonomics, genomics, etc | The baseline and 6 months |
| Gut mircobiome | Retained stool samples tested in metabonomics, genomics, etc | The baseline and 12 months |
| Head Magnetic Resonance Imaging (Head MRI) | Head MRI is used to detect the structure and function of the brain. | The baseline and 3 months |
| Head Magnetic Resonance Imaging (Head MRI) | Head MRI is used to detect the structure and function of the brain. | The baseline and 12 months |
| Functional near - infrared spectroscopy(f-NIRS) | Head fNIRs is a non-invasive, non-ionizing method for measuring and imaging the functional hemodynamic response to brain activity. It measures changes in hemoglobin (Hb) concentrations within the brain by means of the characteristic absorption spectra of Hb in the near-infrared range. | The baseline and 3 months |
| Functional near - infrared spectroscopy(f-NIRS) | Head fNIRs is a non-invasive, non-ionizing method for measuring and imaging the functional hemodynamic response to brain activity. It measures changes in hemoglobin (Hb) concentrations within the brain by means of the characteristic absorption spectra of Hb in the near-infrared range. | The baseline and 6 months |
| Functional near - infrared spectroscopy(f-NIRS) | Head fNIRs is a non-invasive, non-ionizing method for measuring and imaging the functional hemodynamic response to brain activity. It measures changes in hemoglobin (Hb) concentrations within the brain by means of the characteristic absorption spectra of Hb in the near-infrared range. | The baseline and 12 months |
| Multichannel Electroencephalography signals | The latency and amplitude measured by electroencephalogram can reflect the connectivity between brain regions. | The baseline and 3 months |
| Multichannel Electroencephalography signals | The latency and amplitude measured by electroencephalogram can reflect the connectivity between brain regions. | The baseline and 6 months |
| Multichannel Electroencephalography signals | The latency and amplitude measured by electroencephalogram can reflect the connectivity between brain regions. | The baseline and 12 months |
| Eye movements | Variables measured by eye movements represent cognition. | The baseline and 3 months |
| Eye movements | Variables measured by eye movements represent cognition. | The baseline and 6 months |
| Eye movements | Variables measured by eye movements represent cognition. | The baseline and 12 months |
| Behaviour assessment | The behaviour development of participants includes intellectual/developmental quotient, syptoms severity, comorbidity, etc. | The baseline and 6 months |
| Behaviour assessment | The behaviour development of participants includes intellectual/developmental quotient, syptoms severity, comorbidity, etc. | The baseline and 12 months |