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To investigate the effect of citalopram, a selective serotonin reuptake inhibitor, on esophageal sensitivity.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Citalopram | Active Comparator | Administration of citalopram to assess the esophageal sensitivity in HV |
|
| Placebo | Placebo Comparator | Administration of placebo to assess the esophageal sensitivity in HV |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Citalopram | Drug | 40 mg citalopram intravenously |
| |
| Placebo |
| Measure | Description | Time Frame |
|---|---|---|
| Change in sensitivity to thermal stimulation | To detect changes in thermal stimulation for sensitivity | After 1 hour 30 minutes after administration citalopram, we will start with the thermal stimulation |
| Measure | Description | Time Frame |
|---|---|---|
| Change in sensitivity to mechanical stimulation | To detect changes in mechanical stimulation for sensitivity | After 1 hour 45 minutes after administration citalopram, we will start with the mechanical stimulation |
| Change in sensitivity to electrical stimulation |
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Inclusion Criteria:
Exclusion Criteria:
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| ID | Term |
|---|---|
| D005764 | Gastroesophageal Reflux |
| ID | Term |
|---|---|
| D015154 | Esophageal Motility Disorders |
| D003680 | Deglutition Disorders |
| D004935 | Esophageal Diseases |
| D005767 | Gastrointestinal Diseases |
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| ID | Term |
|---|---|
| D015283 | Citalopram |
| ID | Term |
|---|---|
| D011437 | Propylamines |
| D000588 | Amines |
| D009930 | Organic Chemicals |
| D009570 | Nitriles |
| D001572 |
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| Drug |
Saline solution |
|
To detect changes in electrical stimulation for sensitivity |
| After 2 hours after administration citalopram, we will start with the electrical stimulation |
| Change in sensitivity to chemical stimulation | To detect changes in chemical stimulation for sensitivity | After 2 hours 15 minutes after administration citalopram, we will start with the chemical stimulation |
| Change in positive and negative affect score | To detect change in affect of the multimodal stimulation using the PANAS = Positive and Negative Affect scale that consists of two 10-item scales to measure both positive and negative affect. Higher score on the Positive scale is better; Higher score on the Negative Affect scale is worse. | At the beginning of the study and at the end of the multimodal stimulation |
| Change in state trait and anxiety score | to detect changes in the score due to the multimodal stimulation using the The State-Trait Anxiety Inventory (STAI). Each type of anxiety has its own scale of 20 different questions that are scored.Scores range from 20 to 80, with higher scores correlating with greater anxiety. | At the beginning of the study and at the end of the multimodal stimulation |
| D004066 | Digestive System Diseases |
| Benzofurans |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D006571 | Heterocyclic Compounds |