Effect of Citalopram on Reflux Episodes in Healthy Volunteers

Effect of Citalopram on Fasting and Postprandial Lower Esophageal Sphincter Function in Healthy Subjects: a Double-blind, Placebo-controlled, Randomized, Cross-over Study

Citalopram is sometimes used in the treatment for gastro-esophageal reflux disease, however, there are no empirical data to support this. The investigators would like to know if citalopram has an effect on the lower esophageal sphincter pressure, transient lower esophageal sphincter relaxations and reflux episodes. The investigators will investigate this by performing high resolution impedance manometry in healthy volunteers before and after a solid meal. This will be compared to placebo, in a cross-over, randomized, double-blind condition.

Inclusion Criteria:

• between 18 and 65 years

Exclusion Criteria:

• history of upper GI symptoms
• history of upper GI surgery
• psychological disorders
• any drug history
• use of medication altering GI motility
• nursing and pregnant woman