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The purpose of this study is to test whether ultrasound images (pictures) can be used as a valid assessment of muscle quality in different muscle groups during Intensive Care stay. This new approach would allow clinicians to obtain frequent skeletal muscle images and would enable doctors to observe any changes over time in muscle quality that could occur during ICU stay.
Participants in this study will have ultrasound images made of their leg-, chest- and jaw muscles taken on every day until ICU discharge.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Duke ICU/Trauma Center Patients | Any patient admitted to the Duke Trauma Center or Duke ICU will be approached to participate in this study. |
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| Measure | Description | Time Frame |
|---|---|---|
| Muscle Quality from the rectus femoris, vastus lateralis, intermedius, intercostalis, temporalis and styloglossus | Ultrasound-derived area of intramuscular adipose tissue (IMAT) and intramuscular glycogen content from the rectus femoris, vastus lateralis, intermedius, intercostalis, temporalis and styloglossus | Minimum of every other day while in ICU (up to 10 days). Once discharged from ICU minimum of 3x a week until discharge (up to 3 weeks) |
| Muscle volume and thickness from the rectus femoris, vastus lateralis, intermedius, intercostalis, temporalis and styloglossus | Ultrasound-derived volume and thicknessfrom the rectus femoris, vastus lateralis, intermedius, intercostalis, temporalis and styloglossus | Minimum of every other day while in ICU (up to 10 days). Once discharged from ICU minimum of 3x a week until discharge (up to 3 weeks) |
| Measure | Description | Time Frame |
|---|---|---|
| Changes of Intramuscular adipose tissue (IMAT) content and muscle volume/thickness from the psoas at the Level of L3/L4 | the change over time of (standard of care) CT-derived area of intramuscular adipose tissue in cm2 | Up to 1 year |
| Changes of Intramuscular adipose tissue (IMAT) content and muscle volume/thickness from the intercostal muscle at the Level of Th3/Th4 |
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Inclusion Criteria:
Exclusion Criteria:
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All patients admitted to a Duke Trauma center, SICU, MICO, or CT ICU
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| Name | Affiliation | Role |
|---|---|---|
| Paul Wischmeyer | Duke University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Duke University | Durham | North Carolina | 27710 | United States |
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the change over time of (standard of care) CT-derived area of intramuscular adipose tissue in cm2 |
| Up to 1 year |
| Changes of Intramuscular adipose tissue (IMAT) content and muscle volume/thickness from the intercostal muscle at the Level of the head | the change over time of (standard of care) CT-derived area of intramuscular adipose tissue in cm2 | Up to 1 year |