Efficacy of Diacerein on Ocular Surface Disease in Degenerative Arthritis Patients

Efficacy of Diacerein on Ocular Surface Disease in Degenerative Arthritis Patients

Dry eyes is multi-factorial disease which inflammation play etiological role. Diacerein is drug which has anti-inflammatory effect by antagonist Interleukin-1, decrease Interleukin-1 receptor, increase Interleukin-1 Receptor antagonist. This observational study enrolled participants who going to take diacerein for osteoarthritis, measure corneal staining score, Ocular surface disease index score, Tear Osmolarity, Tear break up time, Schirmer 1 test, Interleukin-1 Receptor antagonist, Interleukin-1 alpha, Interleukin-1 beta level in tear at the time of enrollment and after 2 months.

Inclusion Criteria:

1. Osteoarthritis with
2. Ocular surface index score ≥ 13 with
3. Corneal staining score ≥ 3

Exclusion Criteria:

1. Allergic to diacerein
2. Use Cyclosporin within 30 days
3. Eyelid problem
4. Change artificial tear while in the study
5. Pregnancy or breast feeding