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Dry eyes is multi-factorial disease which inflammation play etiological role. Diacerein is drug which has anti-inflammatory effect by antagonist Interleukin-1, decrease Interleukin-1 receptor, increase Interleukin-1 Receptor antagonist. This observational study enrolled participants who going to take diacerein for osteoarthritis, measure corneal staining score, Ocular surface disease index score, Tear Osmolarity, Tear break up time, Schirmer 1 test, Interleukin-1 Receptor antagonist, Interleukin-1 alpha, Interleukin-1 beta level in tear at the time of enrollment and after 2 months.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Diacerein group | Osteoarthritis and dry eye patients treated with Diacerein |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Diacerein | Drug | Diacerein prescribing by orthopedist. Dry eye sign and symptom was asses before start diacerein and after 2 months. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Corneal staining score change from baseline at 2 months | Stain Cornea with Fluorescine, count and score staining at the cornea according to National eye institute : score 0-15 (0=no staining) | At the time of enrollment and 2 months |
| Measure | Description | Time Frame |
|---|---|---|
| Ocular surface disease index score | Ocular Surface Disease Index : 0-100 (0=no any symptom) | At the time of enrollment and 2 months |
| Tear Osmolarity | Use Tearlab to measure tear osmolarity |
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Inclusion Criteria:
Exclusion Criteria:
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Patients diagnosed with osteoarthritis that prescribed Diacerein at out-patient clinic, Department of Orthopedic, King Chulalongkorn Memorial Hospital
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| Name | Affiliation | Role |
|---|---|---|
| Ngamjit Kasetsuwan | Department of Ophthalmology, Chulalongkorn University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Faculty of medicine, Chulalongkorn university | Bangkok | 10330 | Thailand |
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| ID | Term |
|---|---|
| D010003 | Osteoarthritis |
| D015352 | Dry Eye Syndromes |
| ID | Term |
|---|---|
| D001168 | Arthritis |
| D007592 | Joint Diseases |
| D009140 | Musculoskeletal Diseases |
| D012216 | Rheumatic Diseases |
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| ID | Term |
|---|---|
| C025292 | diacerein |
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Tears within Schirmer paper
| At the time of enrollment and 2 months |
| Tear break up time | Stain Cornea with Fluorescine, wait until tear film break, record time that tear break | At the time of enrollment and 2 months |
| Schirmer 1 test | place Schirmer strip at the fornix without anesthesia, wait for 5 min, record tear distance | At the time of enrollment and 2 months |
| Interleukin-1 receptor antagonist, Interleukin-1 alpha, Interleukin-1 beta level in tear | Extract tear from Schirmer strip and use Bioplex for cytokine measurement of Interleukin-1 receptor antagonist(picogram/ml), Interleukin-1 alpha(picogram/ml), Interleukin-1 beta(picogram/ml) | At the time of enrollment and 2 months |
| D007766 |
| Lacrimal Apparatus Diseases |
| D005128 | Eye Diseases |