Symptomatic Efficacy of Diacerein in Knee Osteoarthritis

Efficacy Study of Diacerein in the Symptomatic Treatment of Knee Osteoarthritis

Pain is the main symptom of osteoarthritis that motivates medical visits. Diacerhein has already demonstrated its efficacy in knee and/or hip osteoarthritis. This study aims at confirming the efficacy of diacerhein in symptomatic knee osteoarthritis using known and validated criteria and according to the recommendations and guidelines for this kind of study.

Inclusion Criteria:

• Painful primary osteoarthritis (VAS ≥ 40 mm)
• Radiologically proven (Kellgren & Lawrence grade I to III)
• Requiring the prescription of a symptomatic treatment of pain

Exclusion Criteria:

• Severe associated diseases
• Wash-out: AINS, Coxibs, Paracetamol, anti-osteoarthritic treatments, hyaluronic acid, knee tidal lavage
• Other osteoarticular disease