Home-based Cognitive Monitoring in MCI

Usefulness of a Home-based Cognitive Monitoring in Non-demented Patients With High-risk of Dementia: a Prospective Observational Study

This study is an observational study to confirm usefulness of a home-based cognitive monitoring in non-demented patients with high-risk of dementia

We prospectively enroll subjects who were diagnosed as mild cognitive impairment based on neuropsychological tests battery, brain MRI, and routine blood labs including thyroid function tests, vitamine B12 & folate levels, and syphilis screening to rule out other secondary causes of dementia. We undergo peripheral blood-based amyloid beta levels and regular home-based cognitive monitoring (every 3 months) to investigate whether amyloid-positive MCIs progress rapidly using home-based cognitive monitoring during 6 months.

Inclusion Criteria:

• persistent cognitive complaints
• aged 50 years old or older
• below -1.0 standard deviation in any domain of detailed neuropsychological tests battery named SNSB (Seoul neuropsychological screening battery)
• no ADL (activities of daily living) limitation
• subjects who agreed to participate

Exclusion Criteria:

• dementia patients
• other structural brain disorders such as hydrocephalus, hemorrhage, or tumors
• other neurological disease such as Huntington's disease, Parkinson's disease, or epilepsy