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This study is an observational study to confirm usefulness of a home-based cognitive monitoring in non-demented patients with high-risk of dementia
We prospectively enroll subjects who were diagnosed as mild cognitive impairment based on neuropsychological tests battery, brain MRI, and routine blood labs including thyroid function tests, vitamine B12 & folate levels, and syphilis screening to rule out other secondary causes of dementia. We undergo peripheral blood-based amyloid beta levels and regular home-based cognitive monitoring (every 3 months) to investigate whether amyloid-positive MCIs progress rapidly using home-based cognitive monitoring during 6 months.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| high risk MCI | MCI patients with amyloid beta positive (based on peripheral blood level) |
| |
| low risk MCI | MCI patients with amyloid beta negative (based on peripheral blood level) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| home-based cognitive monitoring | Diagnostic Test | a newly developed home-based cognitive monitoring (about 3-5 minutes per test; total score ranges from 0~30; higher score indicates better cognition) |
| Measure | Description | Time Frame |
|---|---|---|
| home-based cognitive monitoring score | a 3-5 minutes brief cognitive testing (range 0~30, higher score means better outcome) using telephone | 3 months (at baseline, 3 months from baseline, 6 months from baseline) |
| Measure | Description | Time Frame |
|---|---|---|
| Hippocampal atrophy grade | baseline brain MRI markers for hippocampal atrophy using Scheltens' visual rating scale (range 0~4, higher score means more hippocampal atrophy) | at baseline |
| Number of lacunes |
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Inclusion Criteria:
Exclusion Criteria:
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clinically diagnosed mild cognitive impairment according to Petersen's criteria
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| YunJeong Hong, MD,PhD | Contact | 820318203933 | hyj2009@hanmail.net |
| Name | Affiliation | Role |
|---|---|---|
| YunJeong Hong, MD, PhD | Uijeongbu St. Mary's Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Uijeongbu St. Mary's hospital | Recruiting | Uijeongbu-si | 11765 | South Korea |
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| ID | Term |
|---|---|
| D060825 | Cognitive Dysfunction |
| ID | Term |
|---|---|
| D003072 | Cognition Disorders |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
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number of lacunes using manual counting on brain MRI (no limit)
| at baseline |
| Number of microbleeds | number of microbleeds using manual counting on brain MRI (no limit) | at baseline |