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In this study, the investigates try to confirm our hypothesis that low dose ticagrelor(60mg) had similar anti-platelets function compared with the standard dose ticagrelor in senior (no less than 75 years old)acute coronary syndrome patients . Totally 40 senior ACS patients will be divided into 2 groups randomly one month after PCI . Group 1 will be treated with ticagrelor 90mg and aspirin 100mg after PCI for 12 months as the standard group; Group 2 will be treated with ticagrelor 60mg plus aspirin 100 mg for 11 months after one month standard DAPT treatment. The platelets function will be tested in VASP and TEG methods 2 months after PCI as the primary endpoints.The clinical events will be observed 12 months after PCI.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| standard dose ticargrelor based DAPT therapy | Active Comparator | treated with ticagrelor 90mg and aspirin 100mg after PCI for 12 months as the standard group |
|
| low dose ticargrelor based DAPT | Experimental | treated with ticagrelor 60mg plus aspirin 100 mg for 11 months after one month standard DAPT treatment |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ticagrelor | Drug | 90mg ticargrelor based DAPT vs 60mg ticargrelor based DAPT |
|
| Measure | Description | Time Frame |
|---|---|---|
| changes of PRI detected by VASP methods | platelet reactivity index (PRI) detected by VASP (Vasodilator Stimulated | changes of PRI from baseline (4weeks after index PCI) to 8 and 12 weeks after index PCI |
| changes of Maximum Amplitude (MA) detected by TEG | Maximum Amplitude (MA) detected by TEG(Thromboelastography) | changes of MA from baseline (4weeks after index PCI) to 8 and 12 weeks after index PCI |
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Inclusion Criteria:
1.Subject must be at least 75 years of age 2 Patients should have undergone successful percutaneous coronary intervention with drug-eluting stent for acute coronary syndrome 3.Subject understand the study requirements and the treatment procedures and provided informed consent before the procedure
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Lei Hou, Doctor | Contact | 13564868096 | Dr_houlei@163.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| shanghai Tongren hospital | Recruiting | Shanghai | Shanghai Municipality | 200336 | China |
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| ID | Term |
|---|---|
| D000077486 | Ticagrelor |
| ID | Term |
|---|---|
| D000241 | Adenosine |
| D011684 | Purine Nucleosides |
| D011687 | Purines |
| D006574 | Heterocyclic Compounds, 2-Ring |
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| D000072471 |
| Heterocyclic Compounds, Fused-Ring |
| D006571 | Heterocyclic Compounds |
| D009705 | Nucleosides |
| D009706 | Nucleic Acids, Nucleotides, and Nucleosides |
| D012263 | Ribonucleosides |