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| Name | Class |
|---|---|
| Shanghai Jiao Tong University School of Medicine | OTHER |
| Fudan University | OTHER |
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This study is to evaluate the safety and efficacy of 60mg ticagrelor plus 100mg Aspirin to prevent major adverse cardiovascular and cerebrovascular events in one years after drug-eluting stents implantation for Chinese ACS patients compared with 90mg ticagrelor plus 100mg Aspirin
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| low dose ticagrelor | Experimental | After treated with ticagrelor 90mg twice daily and aspirin 100mg once daily for a week,subjects will be treated with ticagrelor 60mg twice daily and aspirin 100mg once daily for until one year after drug eluting stent implantation |
|
| standard dose ticagrelor | Active Comparator | subjects will be treated with ticagrelor 90mg twice daily and aspirin 100mg once daily for a year since drug eluting stent implantation |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ticagrelor 60mg | Drug | Ticagrelor 60mg plus Aspirin 100mg for experimental group |
| |
| Measure | Description | Time Frame |
|---|---|---|
| a composite of cardiovascular death, non-fatal myocardial infarction, stent thrombosis,coronary revascularization,stroke, and bleeding events of BARC grade ≥2 | a composite of death from coronary vascular causes,non-fatal myocardial infarction,stent thrombosis,coronary revascularization, stroke and bleeding type 2, 3 or 5 according to the Bleeding Academic Research Consortium (BARC) criteria | Stent implantation to 12 months |
| Measure | Description | Time Frame |
|---|---|---|
| bleeding events of BARC grade ≥2 | bleeding type 2, 3 or 5 according to the Bleeding Academic Research Consortium (BARC) criteria | Stent implantation to 12 months |
| a composite of cardiovascular death, non-fatal myocardial infarction, stent thrombosis,coronary revascularization,stroke |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Lei Hou, Doctor | Contact | 13564868096 | Dr_houlei@163.com | |
| Junbo Ge, Doctor | Contact | Ge.junbo@zs-hospital.sh.cn |
| Name | Affiliation | Role |
|---|---|---|
| Junbo Ge, Doctor | Fudan University | Study Chair |
| Lei Hou, Doctor | Shanghai Tong Ren Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Taishan people's hospital | Recruiting | Taishan | Guangdong | 529200 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 35248132 | Derived | Pang Y, Ma M, Xia J, Wang D, YanChen, Ye J, Jia Z, Wu S, Yang J, Hou L. A randomized non-inferiority study of low-dose and standard-dose ticagrelor after intervention for acute coronary syndrome: study protocol for the TIGER STUDY. Trials. 2022 Mar 5;23(1):203. doi: 10.1186/s13063-022-06124-z. |
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| ID | Term |
|---|---|
| D054058 | Acute Coronary Syndrome |
| ID | Term |
|---|---|
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D014652 | Vascular Diseases |
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| ID | Term |
|---|---|
| D000077486 | Ticagrelor |
| ID | Term |
|---|---|
| D000241 | Adenosine |
| D011684 | Purine Nucleosides |
| D011687 | Purines |
| D006574 | Heterocyclic Compounds, 2-Ring |
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| Ticagrelor 90mg |
| Drug |
Ticagrelor 90mg plus Aspirin 100mg for active comparator group |
|
a composite of cardiovascular death, non-fatal myocardial infarction, stent thrombosis,coronary revascularization,stroke |
| Stent implantation to 12 months |
| South East of Shandong hospital | Recruiting | Liaocheng | Shandong | China |
|
| zhangshan hospital, Fudan University | Not yet recruiting | Shanghai | Shanghai Municipality | 200032 | China |
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| shanghai Tongren hospital | Recruiting | Shanghai | Shanghai Municipality | 200050 | China |
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| Minhang hospital, Fudan University | Not yet recruiting | Shanghai | Shanghai Municipality | 201100 | China |
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| Songjiang hospital, Shanghai jiaotong university, school of medicine | Not yet recruiting | Shanghai | Shanghai Municipality | China |
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| Ningbo 4th hospital | Recruiting | Xiangshan | Zhejiang | China |
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| Yanzhou branch of affiliated hospital of Jining medical university | Not yet recruiting | Jining | China |
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| D000072471 |
| Heterocyclic Compounds, Fused-Ring |
| D006571 | Heterocyclic Compounds |
| D009705 | Nucleosides |
| D009706 | Nucleic Acids, Nucleotides, and Nucleosides |
| D012263 | Ribonucleosides |