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| Name | Class |
|---|---|
| AE Foundation | OTHER |
| Central Institute of Mental Health, Mannheim | OTHER |
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This study will test the impacts of real time fMRI neurofeedback in patients with Borderline Personality Disorder. This is a pilot study in a small number of people enrolled in clinical programs at Yale New Haven Hospital.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Experimental | Experimental | Neurofeedback in conjunction with Dialectical Behavior Therapy |
|
| Control | No Intervention | Dialectical Behavior Therapy (treatment as usual) |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| real time fMRI neurofeedback | Behavioral | Participants will use real time feedback about their amygdala activity to learn to decrease amygdala activity. |
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| Measure | Description | Time Frame |
|---|---|---|
| Change in Affective Lability | This outcome will be measured by the change in variance of negative emotions measured using ecologic momentary assessment (EMA: surveys sent to participants by smartphone app) repeatedly over a four-day period at each timepoint. The variance between measurements at each timepoint will be calculated, and compared to the other timepoints. There will be 5 negative emotion items at each timepoint, and a higher score indicates more negative emotion. | Baseline compared to the week after intervention |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Mean Negative Affect | This outcome will be measured by change in mean negative emotion score measured using ecologic momentary assessment (EMA: surveys sent to participants by smartphone app) repeatedly over a four-day period at each timepoint. The mean score at each timepoint will be calculated, and compared to the other timepoints. There will be 5 negative emotion items at each timepoint, and a higher score indicates more negative emotion. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Sarah K Fineberg, MD PhD | Yale University | Principal Investigator |
| Michelle Hampson, PhD | Yale University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Connecticut Mental Health Center | New Haven | Connecticut | 06519 | United States |
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| ID | Term |
|---|---|
| D001883 | Borderline Personality Disorder |
| ID | Term |
|---|---|
| D010554 | Personality Disorders |
| D001523 | Mental Disorders |
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| Baseline compared to the week after intervention |
| Change in Borderline Personality Disorder Symptoms | This outcome will be measured by change in Borderline Symptom List (BSL-23) score after neurofeedback. This scale has 23 items, each scored 0-4, and total score is mean item endorsement (sum of all items divided by 23). Higher scores indicate more symptom endorsement. | Baseline compared to the week after intervention |
| Change in Amygdala Regulation | Change in ability to regulate amygdala activity when exposed to provocative images. Amygdala activity is measured as functional magnetic resonance imaging (fMRI) blood oxygen dependant (BOLD) signal | Baseline compared to the week after intervention |