24 Vs 48 Hours of Cefazolin or Cefuroxime as Prophylaxis

24 Versus 48 Hours of First Generation or Second Generation Cephalosporin as Prophylaxis to Reduce Surgical Site Infection in Adult Cardiac Surgery Patients: a Randomized Controlled Trial

A randomized control trial studying the effect of prophylactic antibiotics to reduce surgical site infections following cardiac surgery in adults using 1st generation cephalosporin (Cefazolin) or 2nd generation cephalosporin (Cefuroxime).

A prospective randomized controlled patient blinded study with 2x2 factional design. It aims to study optimal duration of antibiotic to reduce surgical site infections following cardiac surgery in adults 24 or 48 hours using 1st generation cephalosporin (Cefazolin) or 2nd generation cephalosporin (Cefuroxime). Patients shall remain on either medicines for 24 or 48 hours. The primary endpoints of the study are:(1) 48 hours antibiotic prophylaxis is superior to 24 hours in adult cardiac surgery (2) Cefuroxime is superior to Cafazolin as a prophylactic antibiotic in adult cardiac surgery. Secondary endpoints include; organisms causing surgical site infections, length of hospital and ICU stay, and worsening in renal function.

Inclusion Criteria:

• Ability to provide informed consent
• Planned to undergo a cardiac surgical procedure

Exclusion Criteria:

• Patients on antibiotics on the day of surgery or those who received any within 7 days for any reason
• Patients taken to operating room as salvage
• Patients who are allergic to either cefuroxime or cefazolin
• Patients for LVAD or ECMO
• Patients who are known MRSA carriers
• Patients receiving steroid therapy