A randomized controlled trial on adults who underwent orthopedic surgery. To evaluate the effectiveness of intraoperative continuous infusion (CI) of cefazolin compared with intermittent (INT) cefazolin administration in preventing SSIs in the orthopedic surgical population.

Eligible patients will be randomized in a block design into 2 groups: intervention and control. The intervention group will use continuous infusion of cefazolin (CI), while the control group will follow the traditional presurgical prophylaxis protocol of intermittent cefazolin doses (INT).

Inclusion Criteria:

• Orthopaedic surgical ward patients who underwent major surgery.

Exclusion Criteria:

• Patients who require reoperation within 30 days.
• Immunosuppressant patients.
• Patients who are not adherent to the protocol time or dosing, either preoperatively, during, or postoperatively.
• Pregnancy or breastfeeding.