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The study evaluates the effect of coenzyme q 10 on ovulation and subsequent pregnancy in women with polycystic ovarian syndrome. Half of the participants will receive coq10 and ovulation induction with clomiphene and other half would receive a placebo with clomiphene.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Clomiphene | Active Comparator | clomiphene citrate 150 mg once a day for 5 days |
|
| clomiphene and coenzyme q10 | Experimental | clomiphene citrate 150 mg once a day for 5 days and coenzyme q 10 120 mg each day |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Coenzyme Q10 | Drug | antioxidant used to decrease oxidative stress and improve fertility prospects |
|
| Measure | Description | Time Frame |
|---|---|---|
| number of ovulating women | transvaginal ultrasound as the disappearance of the leading follicle, presence of follicular fluid in the Douglas pouch and midluteal progesterone >5 pg/ml. | 1-2 months |
| number of pregnancies | ultrasound visualization of gestational sac with pulsating fetal pole | 1-2 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Rubina Izhar | Aziz Medical Center | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Aziz medical center | Karachi | Sindh | 74600 | Pakistan |
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| ID | Term |
|---|---|
| C024989 | coenzyme Q10 |
| D002996 | Clomiphene |
| ID | Term |
|---|---|
| D013267 | Stilbenes |
| D001597 | Benzylidene Compounds |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
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| clomiphene citrate | Drug | ovulation induction drug |
|
|
| D006844 |
| Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D009930 | Organic Chemicals |